Doxapram and aminophylline on bispectral index under sevoflurane anaesthesia: A comparative study

C. C. Wu, Chao-Shun Lin, Gong-Jhe Wu, Y. H. Lin, Yuan-Wen Lee, Jui Yuan Chen, M. S. Mok

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Background and objective: To evaluate and compare the effect of two clinically available central nervous system stimulants, namely doxapram and aminophylline on arousal from sevoflurane anaesthesia and bispectral index. Methods: This randomized, double-blind, placebo-controlled, prospective study was conducted in 90 adult females, ASA I-II, scheduled for elective lower abdominal surgeries at Taipei Medical University Hospital. At 5 min before the completion of surgery, under sevoflurane anaesthesia, patients were divided into three groups to receive doxapram 1 mg kg-1, aminophylline 2 mg kg-1 or saline placebo intravenous. Standard vital signs, end-tidal CO2, end-expiratory sevoflurane concentration, bispectral index and neuromuscular blockade were measured plus clinical parameters of recovery from general anaesthesia. Results: Compared with the control group, patients receiving doxapram or aminophylline showed a similarly faster recovery from sevoflurane anaesthesia correlated with increase in bispectral index. Conclusion: Intravenous administration of doxapram 1 mg kg-1 or aminophylline 2 mg kg-1 hastened the early recovery from sevoflurane anaesthesia. The arousal effect of aminophylline and doxapram appears to be similar.

Original languageEnglish
Pages (from-to)937-941
Number of pages5
JournalEuropean Journal of Anaesthesiology
Issue number11
Publication statusPublished - Nov 2006


  • Aminophylline
  • Anaesthesia, general
  • Anaesthetics inhalational, sevoflurane
  • Doxapram

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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