TY - JOUR
T1 - Doxapram and aminophylline on bispectral index under sevoflurane anaesthesia
T2 - A comparative study
AU - Wu, C. C.
AU - Lin, Chao-Shun
AU - Wu, Gong-Jhe
AU - Lin, Y. H.
AU - Lee, Yuan-Wen
AU - Chen, Jui Yuan
AU - Mok, M. S.
PY - 2006/11
Y1 - 2006/11
N2 - Background and objective: To evaluate and compare the effect of two clinically available central nervous system stimulants, namely doxapram and aminophylline on arousal from sevoflurane anaesthesia and bispectral index. Methods: This randomized, double-blind, placebo-controlled, prospective study was conducted in 90 adult females, ASA I-II, scheduled for elective lower abdominal surgeries at Taipei Medical University Hospital. At 5 min before the completion of surgery, under sevoflurane anaesthesia, patients were divided into three groups to receive doxapram 1 mg kg-1, aminophylline 2 mg kg-1 or saline placebo intravenous. Standard vital signs, end-tidal CO2, end-expiratory sevoflurane concentration, bispectral index and neuromuscular blockade were measured plus clinical parameters of recovery from general anaesthesia. Results: Compared with the control group, patients receiving doxapram or aminophylline showed a similarly faster recovery from sevoflurane anaesthesia correlated with increase in bispectral index. Conclusion: Intravenous administration of doxapram 1 mg kg-1 or aminophylline 2 mg kg-1 hastened the early recovery from sevoflurane anaesthesia. The arousal effect of aminophylline and doxapram appears to be similar.
AB - Background and objective: To evaluate and compare the effect of two clinically available central nervous system stimulants, namely doxapram and aminophylline on arousal from sevoflurane anaesthesia and bispectral index. Methods: This randomized, double-blind, placebo-controlled, prospective study was conducted in 90 adult females, ASA I-II, scheduled for elective lower abdominal surgeries at Taipei Medical University Hospital. At 5 min before the completion of surgery, under sevoflurane anaesthesia, patients were divided into three groups to receive doxapram 1 mg kg-1, aminophylline 2 mg kg-1 or saline placebo intravenous. Standard vital signs, end-tidal CO2, end-expiratory sevoflurane concentration, bispectral index and neuromuscular blockade were measured plus clinical parameters of recovery from general anaesthesia. Results: Compared with the control group, patients receiving doxapram or aminophylline showed a similarly faster recovery from sevoflurane anaesthesia correlated with increase in bispectral index. Conclusion: Intravenous administration of doxapram 1 mg kg-1 or aminophylline 2 mg kg-1 hastened the early recovery from sevoflurane anaesthesia. The arousal effect of aminophylline and doxapram appears to be similar.
KW - Aminophylline
KW - Anaesthesia, general
KW - Anaesthetics inhalational, sevoflurane
KW - Doxapram
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U2 - 10.1017/S0265021506001220
DO - 10.1017/S0265021506001220
M3 - Article
C2 - 16895622
AN - SCOPUS:33750321747
SN - 0265-0215
VL - 23
SP - 937
EP - 941
JO - European Journal of Anaesthesiology
JF - European Journal of Anaesthesiology
IS - 11
ER -