Double-Stranded RNA Sensing Determines Epithelial Cell Identity

Chung Ping Liao; Edem Tchegnon; Lu Q. Le

doi:10.1016/j.jid.2018.08.008

Double-Stranded RNA Sensing Determines Epithelial Cell Identity

Chung Ping Liao
, Edem Tchegnon
, Lu Q. Le

Research output: Contribution to journal › Comment/debate › peer-review

1 Citation (Scopus)

Abstract

Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.

Original language	English
Pages (from-to)	17-19
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	139
Issue number	1
DOIs	https://doi.org/10.1016/j.jid.2018.08.008
Publication status	Published - Jan 2019

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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10.1016/j.jid.2018.08.008

Cite this

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title = "Double-Stranded RNA Sensing Determines Epithelial Cell Identity",

abstract = "Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.",

author = "Liao, \{Chung Ping\} and Edem Tchegnon and Le, \{Lu Q.\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2019",

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AU - Liao, Chung Ping

AU - Tchegnon, Edem

AU - Le, Lu Q.

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Y1 - 2019/1

N2 - Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.

AB - Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.

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UR - https://www.scopus.com/pages/publications/85056739688#tab=citedBy

U2 - 10.1016/j.jid.2018.08.008

DO - 10.1016/j.jid.2018.08.008

M3 - Comment/debate

C2 - 30579424

AN - SCOPUS:85056739688

SN - 0022-202X

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SP - 17

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JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 1

ER -

Double-Stranded RNA Sensing Determines Epithelial Cell Identity

Abstract

ASJC Scopus subject areas

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