TY - JOUR
T1 - Dosimetric and efficiency comparison of high-dose radiotherapy for esophageal cancer
T2 - Volumetric modulated arc therapy versus fixed-field intensity-modulated radiotherapy
AU - Lin, C. Y.
AU - Huang, W. Y.
AU - Jen, Y. M.
AU - Chen, C. M.
AU - Su, Y. F.
AU - Chao, H. L.
AU - Lin, C. S.
PY - 2014/8
Y1 - 2014/8
N2 - Summary: The aim of this study was to compare high-dose volumetric modulated arc therapy (VMAT) and fixed-field intensity-modulated radiotherapy (ff-IMRT) plans for the treatment of patients with middle-thoracic esophageal cancer. Eight patients with cT2-3N0M0 middle-thoracic esophageal cancer were enrolled. The treatment planning system was the version 9 of the Pinnacle3 with SmartArc (Philips Healthcare, Fitchburg, WI, USA). VMAT and ff-IMRT treatment plans were generated for each case, and both techniques were used to deliver 50Gy to the planning target volume (PTV50) and then provided a 16-Gy boost (PTV66). The VMAT plans provided superior PTV66 coverage compared with the ff-IMRT plans (P = 0.034), whereas the ff-IMRT plans provided more appropriate dose homogeneity to the PTV50 (P = 0.017). In the lung, the V5 and V10 were lower for the ff-IMRT plans than for the VMAT plans, whereas the V20 was lower for the VMAT plans. The delivery time was significantly shorter for the VMAT plans than for the ff-IMRT plans (P = 0.012). In addition, the VMAT plans delivered fewer monitor units. The VMAT technique required a shorter planning time than the ff-IMRT technique (3.8 ± 0.8 hours vs. 5.4 ± 0.6 hours, P = 0.011). The major advantages of VMAT plans are higher efficiency and an approximately 50% reduction in delivery time compared with the ff-IMRT plans, with comparable plan quality. Further clinical investigations to evaluate the use of high-dose VMAT for the treatment of esophageal cancer are warranted.
AB - Summary: The aim of this study was to compare high-dose volumetric modulated arc therapy (VMAT) and fixed-field intensity-modulated radiotherapy (ff-IMRT) plans for the treatment of patients with middle-thoracic esophageal cancer. Eight patients with cT2-3N0M0 middle-thoracic esophageal cancer were enrolled. The treatment planning system was the version 9 of the Pinnacle3 with SmartArc (Philips Healthcare, Fitchburg, WI, USA). VMAT and ff-IMRT treatment plans were generated for each case, and both techniques were used to deliver 50Gy to the planning target volume (PTV50) and then provided a 16-Gy boost (PTV66). The VMAT plans provided superior PTV66 coverage compared with the ff-IMRT plans (P = 0.034), whereas the ff-IMRT plans provided more appropriate dose homogeneity to the PTV50 (P = 0.017). In the lung, the V5 and V10 were lower for the ff-IMRT plans than for the VMAT plans, whereas the V20 was lower for the VMAT plans. The delivery time was significantly shorter for the VMAT plans than for the ff-IMRT plans (P = 0.012). In addition, the VMAT plans delivered fewer monitor units. The VMAT technique required a shorter planning time than the ff-IMRT technique (3.8 ± 0.8 hours vs. 5.4 ± 0.6 hours, P = 0.011). The major advantages of VMAT plans are higher efficiency and an approximately 50% reduction in delivery time compared with the ff-IMRT plans, with comparable plan quality. Further clinical investigations to evaluate the use of high-dose VMAT for the treatment of esophageal cancer are warranted.
KW - Dosimetric comparison
KW - Esophageal cancer
KW - Intensity-modulated radiotherapy
KW - Volumetric modulated arc therapy
UR - http://www.scopus.com/inward/record.url?scp=84905006070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905006070&partnerID=8YFLogxK
U2 - 10.1111/dote.12144
DO - 10.1111/dote.12144
M3 - Article
C2 - 24134466
AN - SCOPUS:84905006070
SN - 1120-8694
VL - 27
SP - 585
EP - 590
JO - Diseases of the Esophagus
JF - Diseases of the Esophagus
IS - 6
ER -
