Dose-response relationship between ischemic heart disease mortality and long-term arsenic exposure

Chien Jen Chen, Hung Yi Chiou, Ming Hsi Chiang, Li Ju Lin, Tong Yuan Tai

Research output: Contribution to journalArticlepeer-review

214 Citations (Scopus)


The cardiovascular effects of inorganic arsenic have been documented, but the dose-response relationship between ischemic heart disease (ISHD) and long-term arsenic exposure remains to be elucidated. Mortality rates from ISHD among residents in 60 villages of the area in Taiwan with endemic arseniasis from 1973 through 1986 were analyzed to examine their association with arsenic concentration in drinking water. Based on 1 355 915 person- years and 217 ISHD deaths, the cumulative ISHD mortalities from birth to age 79 years were 3.4%, 3.5%, 4.7%, and 6.6%, respectively, for residents who lived in villages in which the median arsenic concentrations in drinking water were

Original languageEnglish
Pages (from-to)504-510
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number4
Publication statusPublished - 1996
Externally publishedYes


  • arsenic
  • blackfoot disease
  • ischemic heart disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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