Abstract

The association of arsenic exposure with Chronic Kidney Disease (CKD) has never been reported in low-to-moderate exposed area in Taiwan. The aim of this study is to examine the dose-response relationship between ingested arsenic and CKD in northeastern Taiwan where well arsenic ranged from undetectable to 3590 μg/L. A total of 6,153 participants were followed 1998–2011. The disease status was ascertained through linkage with National Health Insurance database. Cox regression analysis was used to determine the hazard ratio of the disease associated with arsenic exposure. The dose-response relationship between two arsenic exposure indices and CKD was observed. Hazard ratio was 1.00, 0.92 (95% confidence interval (CI), 0.66–1.28), 1.20 (95%CI, 0.90–1.60), 1.46 (95%CI,1.09–1.95), 1.08 (95%CI,0.80– 1.49) and 1.58 (95%CI,1.14–2.18) in relation to well water arsenic concentration of <10.0, 10.0–24.9, 25.0–49.9, 50.0–99.9, 100.0–499.9 and ≥ 500.0 μg/L (Ptrend:0.0099). Significantly increased CKD risk was observed among people consuming contaminated water with arsenic concentration >50 μg/L.

Original languageEnglish
Title of host publicationArsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
EditorsProsun Bhattacharya, Gunnar Jacks, Jochen Bundschuh, Prosun Bhattacharya, Marie Vahter, Jerker Jarsjo, Jerker Jarsjo, Jurate Kumpiene, Arslan Ahmad, Charlotte Sparrenbom, Marinus Eric Donselaar, Jochen Bundschuh, Ravi Naidu, Ravi Naidu
PublisherCRC Press/Balkema
Pages361-362
Number of pages2
ISBN (Print)9781138029415
DOIs
Publication statusPublished - 2016
Event6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, Sweden
Duration: Jun 19 2016Jun 23 2016

Publication series

NameArsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

Conference

Conference6th International Congress on Arsenic in the Environment, AS 2016
Country/TerritorySweden
CityStockholm
Period6/19/166/23/16

ASJC Scopus subject areas

  • Pollution
  • Environmental Chemistry

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