DNA methyltransferase gene dDnmt2 and longevity of Drosophila

Meng Jau Lin, Lin Ya Tang, M. Narsa Reddy, C. K.James Shen

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)


The DNA methylation program of the fruit fly Drosophila melanogaster is carried out by the single DNA methyltransferase gene dDnmt2, the function of which is unknown before. We present evidence that intactness of the gene is required for maintenance of the normal life span of the fruit flies. In contrast, overexpression of dDnmt2 could extend Drosophila life span. The study links the Drosophila DNA methylation program with the small heatshock proteins and longevity/aging and has interesting implication on the eukaryotic DNA methylation programs in general.

Original languageEnglish
Pages (from-to)861-864
Number of pages4
JournalJournal of Biological Chemistry
Issue number2
Publication statusPublished - Jan 14 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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