DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers

Ching Yu Yen; Hurng Wern Huang; Chih Wen Shu; Ming Feng Hou; Shyng Shiou F. Yuan; Hui Ru Wang; Yung Ting Chang; Ammad Ahmad Farooqi; Jen Yang Tang; Hsueh Wei Chang

doi:10.1016/j.canlet.2016.01.036

DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers

Ching Yu Yen, Hurng Wern Huang, Chih Wen Shu, Ming Feng Hou, Shyng Shiou F. Yuan, Hui Ru Wang, Yung Ting Chang, Ammad Ahmad Farooqi, Jen Yang Tang, Hsueh Wei Chang

School of Dentistry

Research output: Contribution to journal › Review article › peer-review

94 Citations (Scopus)

Abstract

Epigenetic modifications play important roles in regulating carcinogenesis, and specific epigenetic modifications have emerged as potential tumor markers. Herein, we summarize several types of epigenetic modifications, explore the role played by epigenetic modifications in gene regulation, and describe the patterns of epigenetic modifications in cancers. Since epigenetic modifications have been reported to regulate the Warburg effect in cancers, the roles of epigenetic modifications in sugar metabolism are discussed. In addition, oxidative stress may play an important role in carcinogenesis, and the role of oxidative stress and epigenetic modification in carcinogenesis is addressed. We also discuss the role of epigenetic modifications as therapeutic targets. Finally, the synergistic effects of the combined treatment of epigenetic regulator and anticancer drugs for cancer therapy are described.

Original language	English
Pages (from-to)	185-192
Number of pages	8
Journal	Cancer Letters
Volume	373
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2016.01.036
Publication status	Published - Apr 10 2016

Keywords

Acetylation
Epigenetic modification
Histone
Methylation
Sugar metabolism

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2016.01.036

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title = "DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers",

abstract = "Epigenetic modifications play important roles in regulating carcinogenesis, and specific epigenetic modifications have emerged as potential tumor markers. Herein, we summarize several types of epigenetic modifications, explore the role played by epigenetic modifications in gene regulation, and describe the patterns of epigenetic modifications in cancers. Since epigenetic modifications have been reported to regulate the Warburg effect in cancers, the roles of epigenetic modifications in sugar metabolism are discussed. In addition, oxidative stress may play an important role in carcinogenesis, and the role of oxidative stress and epigenetic modification in carcinogenesis is addressed. We also discuss the role of epigenetic modifications as therapeutic targets. Finally, the synergistic effects of the combined treatment of epigenetic regulator and anticancer drugs for cancer therapy are described.",

keywords = "Acetylation, Epigenetic modification, Histone, Methylation, Sugar metabolism",

author = "Yen, {Ching Yu} and Huang, {Hurng Wern} and Shu, {Chih Wen} and Hou, {Ming Feng} and Yuan, {Shyng Shiou F.} and Wang, {Hui Ru} and Chang, {Yung Ting} and Farooqi, {Ammad Ahmad} and Tang, {Jen Yang} and Chang, {Hsueh Wei}",

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year = "2016",

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doi = "10.1016/j.canlet.2016.01.036",

language = "English",

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journal = "Cancer Letters",

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T1 - DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers

AU - Yen, Ching Yu

AU - Huang, Hurng Wern

AU - Shu, Chih Wen

AU - Hou, Ming Feng

AU - Yuan, Shyng Shiou F.

AU - Wang, Hui Ru

AU - Chang, Yung Ting

AU - Farooqi, Ammad Ahmad

AU - Tang, Jen Yang

AU - Chang, Hsueh Wei

PY - 2016/4/10

Y1 - 2016/4/10

N2 - Epigenetic modifications play important roles in regulating carcinogenesis, and specific epigenetic modifications have emerged as potential tumor markers. Herein, we summarize several types of epigenetic modifications, explore the role played by epigenetic modifications in gene regulation, and describe the patterns of epigenetic modifications in cancers. Since epigenetic modifications have been reported to regulate the Warburg effect in cancers, the roles of epigenetic modifications in sugar metabolism are discussed. In addition, oxidative stress may play an important role in carcinogenesis, and the role of oxidative stress and epigenetic modification in carcinogenesis is addressed. We also discuss the role of epigenetic modifications as therapeutic targets. Finally, the synergistic effects of the combined treatment of epigenetic regulator and anticancer drugs for cancer therapy are described.

AB - Epigenetic modifications play important roles in regulating carcinogenesis, and specific epigenetic modifications have emerged as potential tumor markers. Herein, we summarize several types of epigenetic modifications, explore the role played by epigenetic modifications in gene regulation, and describe the patterns of epigenetic modifications in cancers. Since epigenetic modifications have been reported to regulate the Warburg effect in cancers, the roles of epigenetic modifications in sugar metabolism are discussed. In addition, oxidative stress may play an important role in carcinogenesis, and the role of oxidative stress and epigenetic modification in carcinogenesis is addressed. We also discuss the role of epigenetic modifications as therapeutic targets. Finally, the synergistic effects of the combined treatment of epigenetic regulator and anticancer drugs for cancer therapy are described.

KW - Acetylation

KW - Epigenetic modification

KW - Histone

KW - Methylation

KW - Sugar metabolism

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DO - 10.1016/j.canlet.2016.01.036

M3 - Review article

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AN - SCOPUS:84958627366

SN - 0304-3835

VL - 373

SP - 185

EP - 192

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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