Diverse apoptotic pathways in enterovirus 71-infected cells

Shih Cheng Chang, Jing Yi Lin, Lily Yen Cheng Lo, Mei Ling Li, Shin Ru Shih

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)


Mechanisms related to the neuropathogenesis of enterovirus 71 infection remain unclear. This investigation conducts a comprehensive study of the apoptotic pathways in neural and non-neural cells following enterovirus 71 infection. Infections with enterovirus 71 not only induce classical cytopathic effects in SF268 (human glioblastoma), SK-N-MC (human neuroblastoma), RD, and Vero cells, but also induce classic signs of apoptosis in all cells, including DNA fragmentation and phosphatidylserine translocation. Apoptosis has also been caused by the efflux of cytochrome c from mitochondria, and subsequently by cleavage of caspase 9 in all cells. Activation of caspase 8 followed by cleavage of the proapoptotic protein Bid only occurs in non-neural cells. Results of this study demonstrate that a mitochondrial pathway of apoptosis mediated by activation and cleavage of caspase 9 is a main pathway in enterovirus 71-induced apoptosis, especially for enterovirus 71-infected neural cells.

Original languageEnglish
Pages (from-to)338-349
Number of pages12
JournalJournal of NeuroVirology
Issue number6
Publication statusPublished - Dec 2004
Externally publishedYes


  • Apoptosis
  • Caspase
  • Cytochrome c
  • Enterovirus 71
  • Mitochondria

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Cellular and Molecular Neuroscience
  • Virology


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