Distribution of systemically administered nanoparticles reveals a size-dependent effect immediately following cardiac ischaemia-reperfusion injury

David J. Lundy; Kun Hung Chen; Elsie K.W. Toh; Patrick C.H. Hsieh

doi:10.1038/srep25613

Distribution of systemically administered nanoparticles reveals a size-dependent effect immediately following cardiac ischaemia-reperfusion injury

David J. Lundy, Kun Hung Chen, Elsie K.W. Toh, Patrick C.H. Hsieh

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

Nanoparticles represent an attractive option for systemic delivery of therapeutic compounds to the heart following myocardial infarction. However, it is well known that physicochemical properties of nanoparticles such as size, shape and surface modifications can vastly alter the distribution and uptake of injected nanoparticles. Therefore, we aimed to provide an examination of the rapid size-dependent uptake of fluorescent PEG-modified polystyrene nanoparticles administered immediately following cardiac ischaemia-reperfusion injury in mice. By assessing the biodistribution of nanoparticles with core diameters between 20 nm and 2 - 1/4m 30 minutes after their administration, we conclude that 20-200 nm diameter nanoparticles are optimal for passive targeting of the injured left ventricle.

Original language	English
Article number	25613
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep25613
Publication status	Published - May 10 2016
Externally published	Yes

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Distribution of systemically administered nanoparticles reveals a size-dependent effect immediately following cardiac ischaemia-reperfusion injury

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