Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages

Dora Livkisa; Tsung-Lin Lee; Wei-Ting Yeh; Manuel S.V. Jaimes; Barbara Szomolay; Chia-Te Liao; David J. Lundy

doi:10.1186/s12979-024-00472-x

Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages

Dora Livkisa, Tsung-Lin Lee, Wei-Ting Yeh, Manuel S.V. Jaimes, Barbara Szomolay, Chia-Te Liao, David J. Lundy

Research output: Contribution to journal › Article › peer-review

Abstract

Previous research has indicated that extracellular vesicles (EVs) potentially play significant roles in multiple ageing phenotypes. This study uses a factorial experimental design to explore the interactions between circulating EVs and bone marrow-derived macrophages (BMDMs) isolated from young (7–12 weeks) and aged (70–90 weeks) mice.

Original language	English
Journal	Immunity and Ageing
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12979-024-00472-x
Publication status	Published - 2024

Keywords

Aging
Ageing
Macrophage
Exosome
Blood plasma
miRNA
Cytokine
Inflammation

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10.1186/s12979-024-00472-x

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title = "Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages",

abstract = "Previous research has indicated that extracellular vesicles (EVs) potentially play significant roles in multiple ageing phenotypes. This study uses a factorial experimental design to explore the interactions between circulating EVs and bone marrow-derived macrophages (BMDMs) isolated from young (7–12 weeks) and aged (70–90 weeks) mice.",

keywords = "Aging, Ageing, Macrophage, Exosome, Blood plasma, miRNA, Cytokine, Inflammation",

author = "Dora Livkisa and Tsung-Lin Lee and Wei-Ting Yeh and Jaimes, {Manuel S.V.} and Barbara Szomolay and Chia-Te Liao and Lundy, {David J.}",

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AU - Livkisa, Dora

AU - Lee, Tsung-Lin

AU - Yeh, Wei-Ting

AU - Jaimes, Manuel S.V.

AU - Szomolay, Barbara

AU - Liao, Chia-Te

AU - Lundy, David J.

PY - 2024

Y1 - 2024

N2 - Previous research has indicated that extracellular vesicles (EVs) potentially play significant roles in multiple ageing phenotypes. This study uses a factorial experimental design to explore the interactions between circulating EVs and bone marrow-derived macrophages (BMDMs) isolated from young (7–12 weeks) and aged (70–90 weeks) mice.

AB - Previous research has indicated that extracellular vesicles (EVs) potentially play significant roles in multiple ageing phenotypes. This study uses a factorial experimental design to explore the interactions between circulating EVs and bone marrow-derived macrophages (BMDMs) isolated from young (7–12 weeks) and aged (70–90 weeks) mice.

KW - Aging

KW - Ageing

KW - Macrophage

KW - Exosome

KW - Blood plasma

KW - miRNA

KW - Cytokine

KW - Inflammation

U2 - 10.1186/s12979-024-00472-x

DO - 10.1186/s12979-024-00472-x

M3 - Article

SN - 1742-4933

VL - 21

JO - Immunity and Ageing

JF - Immunity and Ageing

IS - 1

ER -

Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages

Abstract

Keywords

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