Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size

Dah Shyang Tsai, Tzu Sen Yang, Yu Sheng Huang, Pei Wen Peng, Keng Liang Ou

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Being endowed with an ability of capturing and releasing oxygen, the ceria surface conventionally assumes the role of catalyzing redox reactions in chemistry. This catalytic effect also makes possible its cytotoxicity toward microorganisms at room temperature. To study this cytotoxicity, we synthesized the doped and undoped ceria particles of 8-9 nm in size using an inexpensive precipitation method and evaluated their disinfecting aptitudes with the turbidimetric and plate count methods. Among the samples being analyzed, the silver-doped ceria exhibits the highest sterilization ability, yet the undoped ceria is the most intriguing. The disinfection effect of undoped ceria is moderate in magnitude, demanding a physical contact between the ceria surface and bacteria cell wall, or the redox catalysis that can damage the cell wall and result in the cell killing. Evidently, this effect is short-range and depends strongly on dispersion of the nanoparticles. In contrast, the disinfection effects of silver-doped ceria reach out several millimeters since it releases silver ions to poison the surrounding microorganisms. Additionally, the aliovalent silver substitution creates more ceria defects. The synergetic combination, silver poisoning and heterogeneous redox catalysis, lifts and extends the disinfecting capability of silver-doped ceria to a superior level.

Original languageEnglish
Pages (from-to)2531-2542
Number of pages12
JournalInternational Journal of Nanomedicine
Publication statusPublished - Jun 2 2016


  • Antibacterial activity
  • Ceria nanoparticle
  • Cytotoxicity
  • Oxygen vacancy
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Organic Chemistry
  • Drug Discovery


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