Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma

Wen Ying Liao; Chung Chi Hsu; Tze Sian Chan; Chia Jui Yen; Wei Yu Chen; Hung Wei Pan; Kelvin K. Tsai

doi:10.1016/j.stemcr.2020.02.003

Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma

Wen Ying Liao, Chung Chi Hsu, Tze Sian Chan, Chia Jui Yen, Wei Yu Chen, Hung Wei Pan, Kelvin K. Tsai

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

In this article, Tsai and colleagues investigated the Wnt and stemness heterogeneity in HCC and identified a novel subset of Wnt-activity^high “superpotent cancer stem cells” (spCSCs). The existence of spCSCs is independent of β-catenin mutations and its proportion correlates with poor prognosis in patients with HCC. Mechanistically, spCSCs are positively regulated by the Wnt-ASPM-DVL1 signaling axis through protein-protein interactions.

Original language	English
Pages (from-to)	462-477
Number of pages	16
Journal	Stem Cell Reports
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/j.stemcr.2020.02.003
Publication status	Published - Mar 10 2020

Keywords

ASPM
cancer stem cells
Dishevelled-1
hepatocellular carcinoma
heterogeneity
prognostic marker
ubiquitin ligase
Wnt

ASJC Scopus subject areas

Biochemistry
Genetics
Developmental Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.stemcr.2020.02.003

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title = "Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma",

abstract = "In this article, Tsai and colleagues investigated the Wnt and stemness heterogeneity in HCC and identified a novel subset of Wnt-activityhigh “superpotent cancer stem cells” (spCSCs). The existence of spCSCs is independent of β-catenin mutations and its proportion correlates with poor prognosis in patients with HCC. Mechanistically, spCSCs are positively regulated by the Wnt-ASPM-DVL1 signaling axis through protein-protein interactions.",

keywords = "ASPM, cancer stem cells, Dishevelled-1, hepatocellular carcinoma, heterogeneity, prognostic marker, ubiquitin ligase, Wnt",

author = "Liao, {Wen Ying} and Hsu, {Chung Chi} and Chan, {Tze Sian} and Yen, {Chia Jui} and Chen, {Wei Yu} and Pan, {Hung Wei} and Tsai, {Kelvin K.}",

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doi = "10.1016/j.stemcr.2020.02.003",

language = "English",

volume = "14",

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T1 - Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma

AU - Liao, Wen Ying

AU - Hsu, Chung Chi

AU - Chan, Tze Sian

AU - Yen, Chia Jui

AU - Chen, Wei Yu

AU - Pan, Hung Wei

AU - Tsai, Kelvin K.

PY - 2020/3/10

Y1 - 2020/3/10

N2 - In this article, Tsai and colleagues investigated the Wnt and stemness heterogeneity in HCC and identified a novel subset of Wnt-activityhigh “superpotent cancer stem cells” (spCSCs). The existence of spCSCs is independent of β-catenin mutations and its proportion correlates with poor prognosis in patients with HCC. Mechanistically, spCSCs are positively regulated by the Wnt-ASPM-DVL1 signaling axis through protein-protein interactions.

AB - In this article, Tsai and colleagues investigated the Wnt and stemness heterogeneity in HCC and identified a novel subset of Wnt-activityhigh “superpotent cancer stem cells” (spCSCs). The existence of spCSCs is independent of β-catenin mutations and its proportion correlates with poor prognosis in patients with HCC. Mechanistically, spCSCs are positively regulated by the Wnt-ASPM-DVL1 signaling axis through protein-protein interactions.

KW - ASPM

KW - cancer stem cells

KW - Dishevelled-1

KW - hepatocellular carcinoma

KW - heterogeneity

KW - prognostic marker

KW - ubiquitin ligase

KW - Wnt

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DO - 10.1016/j.stemcr.2020.02.003

M3 - Article

AN - SCOPUS:85081654866

SN - 2213-6711

VL - 14

SP - 462

EP - 477

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 3

ER -

Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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