TY - JOUR
T1 - Discovery of the novel HLA-DRB1*10
T2 - 04 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, -B, -C and -DRB1 haplotype in association with DRB1*10:04
AU - Yang, K. L.
AU - Lee, S. K.
AU - Kao, R. H.
AU - Lin, C. L.
AU - Lin, P. Y.
PY - 2012/10/1
Y1 - 2012/10/1
N2 - We report here a novel variant of HLA-DRB1*10, DRB1*10:04, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*10:04 differs from DRB1*10:01:01, in exon 2, at nucleotide positions 296 (G→A) and 303 (T→G). The nucleotide changes caused an amino acid substitution at amino acid residue 70 (R→Q). We hypothesize that the formation of DRB1*10:04 was probably the result of a gene recombination event where DRB1*10:01:01 received a minimum length of DNA sequence from DRB1*04:05:01, as the sequence of DRB1*10:04 is identical to DRB1*10:01:01 in exon 2 except the sequence from nucleotide 296 to nucleotide 303, which is identical to DRB1*04:05:01. The plausible HLA-A, -B, -C and -DRB1 haplotypes in association with DRB1*10:04 was deduced as A*01:01-B*37:01-C*06:02-DRB1*10:04.
AB - We report here a novel variant of HLA-DRB1*10, DRB1*10:04, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*10:04 differs from DRB1*10:01:01, in exon 2, at nucleotide positions 296 (G→A) and 303 (T→G). The nucleotide changes caused an amino acid substitution at amino acid residue 70 (R→Q). We hypothesize that the formation of DRB1*10:04 was probably the result of a gene recombination event where DRB1*10:01:01 received a minimum length of DNA sequence from DRB1*04:05:01, as the sequence of DRB1*10:04 is identical to DRB1*10:01:01 in exon 2 except the sequence from nucleotide 296 to nucleotide 303, which is identical to DRB1*04:05:01. The plausible HLA-A, -B, -C and -DRB1 haplotypes in association with DRB1*10:04 was deduced as A*01:01-B*37:01-C*06:02-DRB1*10:04.
UR - http://www.scopus.com/inward/record.url?scp=84865862689&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865862689&partnerID=8YFLogxK
U2 - 10.1111/j.1744-313X.2012.01106.x
DO - 10.1111/j.1744-313X.2012.01106.x
M3 - Article
C2 - 23115788
AN - SCOPUS:84865862689
SN - 1744-3121
VL - 39
SP - 448
EP - 450
JO - International Journal of Immunogenetics
JF - International Journal of Immunogenetics
IS - 5
ER -