Discovery of the novel HLA-DRB1*09: 01:08 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08

K. L. Yang; S. K. Lee; S. Y. Yang; R. H. Kao; C. L. Lin; P. Y. Lin

doi:10.1111/j.1744-313X.2012.01143.x

Discovery of the novel HLA-DRB109: 01:08 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB109:01:08

K. L. Yang, S. K. Lee, S. Y. Yang, R. H. Kao, C. L. Lin, P. Y. Lin

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We report here the novel variant of HLA-DRB1*09:01, DRB1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*09:01:08 is identical to the sequence of DRB1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261(C→T) (GCC→GCT at codon 58). We hypothesize DRB1*09:01:08 was probably derived from DRB1*09:01:02 via a nucleotide point mutation event. The plausible HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08 was deduced as A*02:07-B*46:01-DRB1*09:01:08.

Original language	English
Pages (from-to)	149-150
Number of pages	2
Journal	International Journal of Immunogenetics
Volume	40
Issue number	2
DOIs	https://doi.org/10.1111/j.1744-313X.2012.01143.x
Publication status	Published - Apr 1 2013
Externally published	Yes

ASJC Scopus subject areas

Immunology
Molecular Biology
Genetics
Genetics(clinical)

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10.1111/j.1744-313X.2012.01143.x

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Yang, K. L., Lee, S. K., Yang, S. Y., Kao, R. H., Lin, C. L., & Lin, P. Y. (2013). Discovery of the novel HLA-DRB1*09: 01:08 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08. International Journal of Immunogenetics, 40(2), 149-150. https://doi.org/10.1111/j.1744-313X.2012.01143.x

Discovery of the novel HLA-DRB1*09: 01:08 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08. / Yang, K. L.; Lee, S. K.; Yang, S. Y. et al.
In: International Journal of Immunogenetics, Vol. 40, No. 2, 01.04.2013, p. 149-150.

Research output: Contribution to journal › Article › peer-review

Yang, KL, Lee, SK, Yang, SY, Kao, RH, Lin, CL & Lin, PY 2013, 'Discovery of the novel HLA-DRB1*09: 01:08 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08', International Journal of Immunogenetics, vol. 40, no. 2, pp. 149-150. https://doi.org/10.1111/j.1744-313X.2012.01143.x

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abstract = "We report here the novel variant of HLA-DRB1*09:01, DRB1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*09:01:08 is identical to the sequence of DRB1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261(C→T) (GCC→GCT at codon 58). We hypothesize DRB1*09:01:08 was probably derived from DRB1*09:01:02 via a nucleotide point mutation event. The plausible HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08 was deduced as A*02:07-B*46:01-DRB1*09:01:08.",

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Discovery of the novel HLA-DRB109: 01:08 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB109:01:08

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