Disappearing Calvarium in Gorham Disease: MR Imaging Characteristics with Pathologic Correlation

Chung Ping Lo, Cheng Yu Chen, Shy Chyi Chin, Chun Jung Juan, Chun Jen Hsueh, Ann Chen

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26 Citations (Scopus)


Gorham disease is a rare condition characterized by intraosseous neoplastic proliferation of hemangiomatous tissue with progressive, massive osteolysis. We present a pathologically proved case of Gorham disease that involved the left parietal bone in a 23-year-old man. Imaging studies including conventional radiography of the skull, CT, MR imaging, and Technetium-99 m (Tc-99 m) scintigraphy demonstrated a large skull defect without associated soft tissue mass over the left parietal skull. Contrast enhancement and increased isotope uptake along the margin of the defect were shown at gadolinium-enhanced Tl-weighted MR imaging and Tc-99 m methylene diphosphate (Tc-99 m MDP) bone scintigraphy. Pathologic study revealed intraosseous angiomatosis at the periphery of the osteolytic skull lesion.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalAmerican Journal of Neuroradiology
Issue number3
Publication statusPublished - Mar 2004
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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