Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression

Medicine & Life Sciences

• dioscin 100%
• src Homology Domains 67%
• Adenocarcinoma of Lung 59%
• Phosphoric Monoester Hydrolases 56%
• ErbB Receptors 53%
• Tyrosine 51%
• Protein-Tyrosine Kinases 50%
• Down-Regulation 39%
• Mitogen-Activated Protein Kinase Kinases 26%
• Phosphatidylinositol 3-Kinases 23%
• Messenger RNA 9%
• Libraries 7%
• Reactive Oxygen Species 6%
• Recurrence 4%
• Mutation 4%
• Neoplasms 2%
• Therapeutics 1%

Agriculture & Biology

• epidermal growth factor receptors 75%
• adenocarcinoma 66%
• tyrosine 51%
• phosphotransferases (kinases) 47%
• lungs 44%
• phosphatidylinositol 3-kinase 31%
• mitogen-activated protein kinase 26%
• cells 17%
• relapse 10%
• prognosis 9%
• reactive oxygen species 6%
• therapeutics 6%
• neoplasms 6%
• transcription (genetics) 5%
• promoter regions 5%
• mutation 5%

Earth & Environmental Sciences

• phosphatase 61%
• inhibitor 52%
• regulation 39%
• cell 34%
• reactive oxygen species 7%
• therapy 6%
• tumor 6%
• mutation 6%
• amplification 5%
• library 5%