TY - JOUR
T1 - Diffusion capacity predicts long-term survival after allogeneic bone marrow transplantation for acute lymphoblastic leukemia
AU - Chang, Peter Mu Hsin
AU - Chiou, Tzeon Jye
AU - Yen, Chueh Chuan
AU - Hsiao, Liang Tsai
AU - Liu, Jin Hwang
AU - Chen, Po Min
N1 - Funding Information:
This research was supported by the Taiwan Cancer Clinic Research Foundation.
PY - 2008/5
Y1 - 2008/5
N2 - Background: The aim of this study was to evaluate changes in pulmonary function measures as predictors of outcome in acute lymphoblastic leukemia (ALL) patients after myeloablative allogeneic bone marrow transplantation (BMT). Methods: Forced expiratory volume in 1 second (FEV1) and diffusion capacity for carbon monoxide (DLCO) were evaluated before and after allogeneic BMT every 3 months in 32 patients who survived for at least 100 days. General case histories were also examined. Results: Univariate analysis revealed that decreased post-BMT DLCO was associated with increased overall and event-free survival (p < 0.05). While a pre-BMT FEV1 of < 70% was associated with significantly decreased overall survival (p < 0.05), multiple regression analysis indicated that patients without cytomegalovirus (CMV) infection, having limited chronic graft-versus-host disease (GVHD) and with markedly decreased DLCO had better overall survival (p < 0.05). After adjusting for age, gender, chronic GVHD, and CMV infection, patients with decreased DLCO exhibited enhanced overall survival. Two-year survival and event-free survival rates were significantly higher in patients with decreased DLCO. Conclusion: We conclude that DLCO may be a good long-term predictor of outcome in patients with ALL following BMT.
AB - Background: The aim of this study was to evaluate changes in pulmonary function measures as predictors of outcome in acute lymphoblastic leukemia (ALL) patients after myeloablative allogeneic bone marrow transplantation (BMT). Methods: Forced expiratory volume in 1 second (FEV1) and diffusion capacity for carbon monoxide (DLCO) were evaluated before and after allogeneic BMT every 3 months in 32 patients who survived for at least 100 days. General case histories were also examined. Results: Univariate analysis revealed that decreased post-BMT DLCO was associated with increased overall and event-free survival (p < 0.05). While a pre-BMT FEV1 of < 70% was associated with significantly decreased overall survival (p < 0.05), multiple regression analysis indicated that patients without cytomegalovirus (CMV) infection, having limited chronic graft-versus-host disease (GVHD) and with markedly decreased DLCO had better overall survival (p < 0.05). After adjusting for age, gender, chronic GVHD, and CMV infection, patients with decreased DLCO exhibited enhanced overall survival. Two-year survival and event-free survival rates were significantly higher in patients with decreased DLCO. Conclusion: We conclude that DLCO may be a good long-term predictor of outcome in patients with ALL following BMT.
KW - Acute lymphoblastic leukemia
KW - Allogeneic bone marrow transplantation
KW - Chronic graft-versus-host disease
KW - Pulmonary function test
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U2 - 10.1016/S1726-4901(08)70113-8
DO - 10.1016/S1726-4901(08)70113-8
M3 - Article
C2 - 18490227
AN - SCOPUS:44949163652
SN - 1726-4901
VL - 71
SP - 234
EP - 240
JO - Journal of the Chinese Medical Association
JF - Journal of the Chinese Medical Association
IS - 5
ER -