Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix

Chia Wen Chang; Mei Tsu Lin; Shoei Sheng Lee; Karin C S Chen Liu; Feng Lin Hsu; Jung Yaw Lin

doi:10.1016/0166-3542(95)00020-M

Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix

Chia Wen Chang, Mei Tsu Lin, Shoei Sheng Lee, Karin C S Chen Liu, Feng Lin Hsu, Jung Yaw Lin

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

128 Citations (Scopus)

Abstract

Two lignans, phyllamycin B and retrojusticidin B isolated from Phyllanthus myrtifolius Moon have been demonstrated to have a strong inhibitory effect on human immunodeficiency virus-1 reverse transcriptase activity (HIV-1 RT), but much less inhibitory effect on human DNA polymerase-α (HDNAP-α) activity. Fifty percent inhibitory concentrations of phyllamycin B and retrojusticidin B were determined to be 3.5 and 5.5 μM for HIV-1 RT, and 289 and 989 μM for HDNAP-α, respectively. The mode of inhibition was found to be non-competitive inhibition with respect to template-primer and triphosphate substrate. Several tannins such as caffeoylquinates (CQs) isolated from Lonicera japonica Thunb, galloylquinates (GQs) and galloylshikimates (GSs) purified from Castanopsis hystrix were shown to have a much less selective inhibitory effect on HIV-1 RT.

Original language	English
Pages (from-to)	367-374
Number of pages	8
Journal	Antiviral Research
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/0166-3542(95)00020-M
Publication status	Published - 1995

Keywords

Caffeoylquinate
Galloylquinate
Galloylshikimate
Lignan
Reverse transcriptase inhibition

ASJC Scopus subject areas

Virology
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0166-3542(95)00020-M

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Chang, C. W., Lin, M. T., Lee, S. S., Liu, K. C. S. C., Hsu, F. L., & Lin, J. Y. (1995). Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix. Antiviral Research, 27(4), 367-374. https://doi.org/10.1016/0166-3542(95)00020-M

Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix. / Chang, Chia Wen; Lin, Mei Tsu; Lee, Shoei Sheng et al.
In: Antiviral Research, Vol. 27, No. 4, 1995, p. 367-374.

Research output: Contribution to journal › Review article › peer-review

Chang, CW, Lin, MT, Lee, SS, Liu, KCSC, Hsu, FL & Lin, JY 1995, 'Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix', Antiviral Research, vol. 27, no. 4, pp. 367-374. https://doi.org/10.1016/0166-3542(95)00020-M

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abstract = "Two lignans, phyllamycin B and retrojusticidin B isolated from Phyllanthus myrtifolius Moon have been demonstrated to have a strong inhibitory effect on human immunodeficiency virus-1 reverse transcriptase activity (HIV-1 RT), but much less inhibitory effect on human DNA polymerase-α (HDNAP-α) activity. Fifty percent inhibitory concentrations of phyllamycin B and retrojusticidin B were determined to be 3.5 and 5.5 μM for HIV-1 RT, and 289 and 989 μM for HDNAP-α, respectively. The mode of inhibition was found to be non-competitive inhibition with respect to template-primer and triphosphate substrate. Several tannins such as caffeoylquinates (CQs) isolated from Lonicera japonica Thunb, galloylquinates (GQs) and galloylshikimates (GSs) purified from Castanopsis hystrix were shown to have a much less selective inhibitory effect on HIV-1 RT.",

keywords = "Caffeoylquinate, Galloylquinate, Galloylshikimate, Lignan, Reverse transcriptase inhibition",

author = "Chang, {Chia Wen} and Lin, {Mei Tsu} and Lee, {Shoei Sheng} and Liu, {Karin C S Chen} and Hsu, {Feng Lin} and Lin, {Jung Yaw}",

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T1 - Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix

AU - Chang, Chia Wen

AU - Lin, Mei Tsu

AU - Lee, Shoei Sheng

AU - Liu, Karin C S Chen

AU - Hsu, Feng Lin

AU - Lin, Jung Yaw

PY - 1995

Y1 - 1995

N2 - Two lignans, phyllamycin B and retrojusticidin B isolated from Phyllanthus myrtifolius Moon have been demonstrated to have a strong inhibitory effect on human immunodeficiency virus-1 reverse transcriptase activity (HIV-1 RT), but much less inhibitory effect on human DNA polymerase-α (HDNAP-α) activity. Fifty percent inhibitory concentrations of phyllamycin B and retrojusticidin B were determined to be 3.5 and 5.5 μM for HIV-1 RT, and 289 and 989 μM for HDNAP-α, respectively. The mode of inhibition was found to be non-competitive inhibition with respect to template-primer and triphosphate substrate. Several tannins such as caffeoylquinates (CQs) isolated from Lonicera japonica Thunb, galloylquinates (GQs) and galloylshikimates (GSs) purified from Castanopsis hystrix were shown to have a much less selective inhibitory effect on HIV-1 RT.

AB - Two lignans, phyllamycin B and retrojusticidin B isolated from Phyllanthus myrtifolius Moon have been demonstrated to have a strong inhibitory effect on human immunodeficiency virus-1 reverse transcriptase activity (HIV-1 RT), but much less inhibitory effect on human DNA polymerase-α (HDNAP-α) activity. Fifty percent inhibitory concentrations of phyllamycin B and retrojusticidin B were determined to be 3.5 and 5.5 μM for HIV-1 RT, and 289 and 989 μM for HDNAP-α, respectively. The mode of inhibition was found to be non-competitive inhibition with respect to template-primer and triphosphate substrate. Several tannins such as caffeoylquinates (CQs) isolated from Lonicera japonica Thunb, galloylquinates (GQs) and galloylshikimates (GSs) purified from Castanopsis hystrix were shown to have a much less selective inhibitory effect on HIV-1 RT.

KW - Caffeoylquinate

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KW - Galloylshikimate

KW - Lignan

KW - Reverse transcriptase inhibition

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Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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