Differential coronary hemodynamics and left ventricular contractility in patients with syndrome X

Jaw Wen Chen, Nai Wei Hsu, Chih Tai Ting, Shing Jong Lin, Mau Song Chang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The relationship between coronary hemodynamics and left ventricular contractility was studied in 20 patients with syndrome X. Among them, 10 patients with a resting left ventricular ejection fraction (LVEF, by radionuclide method) equal to or greater than the mean value of the whole group (58%) were defined as having relative increased left ventricular contractility (group H), and another 10 patients with relatively normal contractility (50%≤LVEF<58%) were in group N. Eight subjects with normal contractility, exercise test and coronary angiograms served as the control (group C). Baseline great cardiac venous flow (GCVF) was higher in group N than in group H (P<0.05) and C (P<0.05), but similar between group H and C. After dipyridamole infusion (0.56 mg/kg, i.v., for 4 min), maximum GCVF was less in group H than in group N (P<0.001) and C (P<0.001), but similar between group N and C. As compared to group C (3.09±0.35), coronary flow reserve was reduced in both group H (2.34±0.55, P=0.004) and N (2.40±0.36, P=0.001). In all syndrome X patients, resting LVEF was negatively correlated to baseline GCVF (P=0.026) and tended to be positively correlated to baseline coronary vascular resistance (P=0.057). Thus, coronary hemodynamics was altered with left ventricular contractility in syndrome X patients. In these patients, coronary flow reserve was similarly reduced with different underlying mechanisms. The limited increase of GCVF after dipyridamole infusion suggests impaired coronary microvascular dilation capacity in patients with relatively increased left ventricular contractility and the increase of baseline GCVF in those with normal contractility is more likely due to an altered basal myocardial metabolism. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalInternational Journal of Cardiology
Volume75
Issue number1
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Coronary flow reserve
  • Hypercontractility
  • Left ventricular function
  • Syndrome X

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Differential coronary hemodynamics and left ventricular contractility in patients with syndrome X'. Together they form a unique fingerprint.

Cite this