Dicentric Ph1 chromosome

J. Whang Peng; T. A. Knutsen; E. C. Lee

doi:10.1093/jnci/51.6.2009

Dicentric Ph¹ chromosome

J. Whang Peng
, T. A. Knutsen
, E. C. Lee

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Five cases in a chronic myelogenous leukemia series were originally categorized as Ph¹ positive and later developed another variant of the Ph¹ chromosome. With the new Giemsa banding technique, it appeared to be a dicentric Ph¹ chromosome. This chromosome was first noted 23 mth after diagnosis, with the latest appearance at 57 mth. Survival in 3 of the 5 patients after the appearance of the dicentric Ph¹ chromosome was 6, 16, and 35 mth; the other 2 are still alive.

Original language	English
Pages (from-to)	2009-2012
Number of pages	4
Journal	Journal of the National Cancer Institute
Volume	51
Issue number	6
DOIs	https://doi.org/10.1093/jnci/51.6.2009
Publication status	Published - Jan 1 1973
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1093/jnci/51.6.2009

Cite this

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title = "Dicentric Ph1 chromosome",

abstract = "Five cases in a chronic myelogenous leukemia series were originally categorized as Ph1 positive and later developed another variant of the Ph1 chromosome. With the new Giemsa banding technique, it appeared to be a dicentric Ph1 chromosome. This chromosome was first noted 23 mth after diagnosis, with the latest appearance at 57 mth. Survival in 3 of the 5 patients after the appearance of the dicentric Ph1 chromosome was 6, 16, and 35 mth; the other 2 are still alive.",

author = "\{Whang Peng\}, J. and Knutsen, \{T. A.\} and Lee, \{E. C.\}",

note = "Funding Information: 2 Tumor Cell Biology Branch, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md. 20014.",

year = "1973",

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doi = "10.1093/jnci/51.6.2009",

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T1 - Dicentric Ph1 chromosome

AU - Whang Peng, J.

AU - Knutsen, T. A.

AU - Lee, E. C.

N1 - Funding Information: 2 Tumor Cell Biology Branch, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md. 20014.

PY - 1973/1/1

Y1 - 1973/1/1

N2 - Five cases in a chronic myelogenous leukemia series were originally categorized as Ph1 positive and later developed another variant of the Ph1 chromosome. With the new Giemsa banding technique, it appeared to be a dicentric Ph1 chromosome. This chromosome was first noted 23 mth after diagnosis, with the latest appearance at 57 mth. Survival in 3 of the 5 patients after the appearance of the dicentric Ph1 chromosome was 6, 16, and 35 mth; the other 2 are still alive.

AB - Five cases in a chronic myelogenous leukemia series were originally categorized as Ph1 positive and later developed another variant of the Ph1 chromosome. With the new Giemsa banding technique, it appeared to be a dicentric Ph1 chromosome. This chromosome was first noted 23 mth after diagnosis, with the latest appearance at 57 mth. Survival in 3 of the 5 patients after the appearance of the dicentric Ph1 chromosome was 6, 16, and 35 mth; the other 2 are still alive.

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SP - 2009

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JO - Journal of the National Cancer Institute

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