TY - JOUR
T1 - Diagnostic value of EBUS-TBNA for lung cancer with non-enlarged lymph nodes
T2 - A study in a Tuberculosis-Endemic Country
AU - Kuo, Chih Hsi
AU - Chen, Hao Cheng
AU - Chung, Fu Tsai
AU - Lo, Yu Lun
AU - Lee, Kang Yun
AU - Wang, Chih Wei
AU - Kuo, Wen Han
AU - Yen, Tzu Chen
AU - Kuo, Han Pin
PY - 2011
Y1 - 2011
N2 - Background: In tuberculosis (TB)-endemic areas, contrast-enhanced computed tomography (CT) and positron emission tomography (PET) findings of lung cancer patients with non-enlarged lymph nodes are frequently discrepant. Endobronchial ultrasound-guided transbronchial aspiration (EBUS-TBNA) enables real-time nodal sampling, and thereby improves nodal diagnosis accuracy. This study aimed to compare the accuracy of nodal diagnosis by using EBUS-TBNA, and PET. Methods: We studied 43 lung cancer patients with CT-defined non-enlarged mediastinal and hilar lymph nodes and examined 78 lymph nodes using EBUS-TBNA. Results: The sensitivity, specificity, positive predictive value, and negative predictive value of EBUS-TBNA were 80.6%, 100%, 100%, and 85.7%, respectively. PET had low specificity (18.9%) and a low positive predictive value (44.4%). The diagnostic accuracy of EBUS-TBNA was higher than that of PET (91% vs. 47.4%; p
AB - Background: In tuberculosis (TB)-endemic areas, contrast-enhanced computed tomography (CT) and positron emission tomography (PET) findings of lung cancer patients with non-enlarged lymph nodes are frequently discrepant. Endobronchial ultrasound-guided transbronchial aspiration (EBUS-TBNA) enables real-time nodal sampling, and thereby improves nodal diagnosis accuracy. This study aimed to compare the accuracy of nodal diagnosis by using EBUS-TBNA, and PET. Methods: We studied 43 lung cancer patients with CT-defined non-enlarged mediastinal and hilar lymph nodes and examined 78 lymph nodes using EBUS-TBNA. Results: The sensitivity, specificity, positive predictive value, and negative predictive value of EBUS-TBNA were 80.6%, 100%, 100%, and 85.7%, respectively. PET had low specificity (18.9%) and a low positive predictive value (44.4%). The diagnostic accuracy of EBUS-TBNA was higher than that of PET (91% vs. 47.4%; p
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U2 - 10.1371/journal.pone.0016877
DO - 10.1371/journal.pone.0016877
M3 - Article
C2 - 21364919
AN - SCOPUS:79952182941
SN - 1932-6203
VL - 6
JO - PLoS ONE
JF - PLoS ONE
IS - 2
M1 - e16877
ER -
