Developmental origin of postnatal cardiomyogenic progenitor cells

Yuan-Hung Liu; Ling-Ping Lai; Shih-Yun Huang; Yi-Shuan Lin; Shinn-Chih Wu; Chih-Jen Chou; Jiunn-Lee Lin

doi:10.4155/fsoa-2016-0006

Developmental origin of postnatal cardiomyogenic progenitor cells

Yuan-Hung Liu
, Ling-Ping Lai
, Shih-Yun Huang
, Yi-Shuan Lin
, Shinn-Chih Wu
, Chih-Jen Chou
, Jiunn-Lee Lin

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

AIM: To trace the cell origin of the cells involved in postnatal cardiomyogenesis.

MATERIALS & METHODS: Nkx2.5 enhancer-eGFP (Nkx2.5 enh-eGFP) mice were used to test the cardiomyogenic potential of Nkx2.5 enhancer-expressing cells. By analyzing Cre excision of activated Nkx2.5-eGFP+ cells from different lineage-Cre/Nkx2.5 enh-eGFP/ROSA26 reporter mice, we traced the developmental origin of Nkx2.5 enhancer-expressing cells.

RESULTS: Nkx2.5 enhancer-expressing cells could differentiate into striated cardiomyocytes both in vitro and in vivo. Nkx2.5-eGFP+ cells increased remarkably after experimental myocardial infarction (MI). The post-MI Nkx2.5-eGFP+ cells originated from the embryonic epicardial cells, not from the pre-existing cardiomyocytes, endothelial cells, cardiac neural crest cells or perinatal/postnatal epicardial cells.

CONCLUSION: Postnatal Nkx2.5 enhancer-expressing cells are cardiomyogenic progenitor cells and originate from embryonic epicardium-derived cells.

Original language	English
Pages (from-to)	FSO120
Journal	Future Oncology
Volume	2
Issue number	2
DOIs	https://doi.org/10.4155/fsoa-2016-0006
Publication status	Published - Jun 2016
Externally published	Yes

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10.4155/fsoa-2016-0006

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@article{b6c7b37d6b504f779741d12554d2ae71,

title = "Developmental origin of postnatal cardiomyogenic progenitor cells",

abstract = "AIM: To trace the cell origin of the cells involved in postnatal cardiomyogenesis.MATERIALS \& METHODS: Nkx2.5 enhancer-eGFP (Nkx2.5 enh-eGFP) mice were used to test the cardiomyogenic potential of Nkx2.5 enhancer-expressing cells. By analyzing Cre excision of activated Nkx2.5-eGFP+ cells from different lineage-Cre/Nkx2.5 enh-eGFP/ROSA26 reporter mice, we traced the developmental origin of Nkx2.5 enhancer-expressing cells.RESULTS: Nkx2.5 enhancer-expressing cells could differentiate into striated cardiomyocytes both in vitro and in vivo. Nkx2.5-eGFP+ cells increased remarkably after experimental myocardial infarction (MI). The post-MI Nkx2.5-eGFP+ cells originated from the embryonic epicardial cells, not from the pre-existing cardiomyocytes, endothelial cells, cardiac neural crest cells or perinatal/postnatal epicardial cells.CONCLUSION: Postnatal Nkx2.5 enhancer-expressing cells are cardiomyogenic progenitor cells and originate from embryonic epicardium-derived cells.",

author = "Yuan-Hung Liu and Ling-Ping Lai and Shih-Yun Huang and Yi-Shuan Lin and Shinn-Chih Wu and Chih-Jen Chou and Jiunn-Lee Lin",

year = "2016",

month = jun,

doi = "10.4155/fsoa-2016-0006",

language = "English",

volume = "2",

pages = "FSO120",

journal = "Future Oncology",

issn = "2056-5623",

publisher = "Future Medicine Ltd.",

number = "2",

}

TY - JOUR

T1 - Developmental origin of postnatal cardiomyogenic progenitor cells

AU - Liu, Yuan-Hung

AU - Lai, Ling-Ping

AU - Huang, Shih-Yun

AU - Lin, Yi-Shuan

AU - Wu, Shinn-Chih

AU - Chou, Chih-Jen

AU - Lin, Jiunn-Lee

PY - 2016/6

Y1 - 2016/6

N2 - AIM: To trace the cell origin of the cells involved in postnatal cardiomyogenesis.MATERIALS & METHODS: Nkx2.5 enhancer-eGFP (Nkx2.5 enh-eGFP) mice were used to test the cardiomyogenic potential of Nkx2.5 enhancer-expressing cells. By analyzing Cre excision of activated Nkx2.5-eGFP+ cells from different lineage-Cre/Nkx2.5 enh-eGFP/ROSA26 reporter mice, we traced the developmental origin of Nkx2.5 enhancer-expressing cells.RESULTS: Nkx2.5 enhancer-expressing cells could differentiate into striated cardiomyocytes both in vitro and in vivo. Nkx2.5-eGFP+ cells increased remarkably after experimental myocardial infarction (MI). The post-MI Nkx2.5-eGFP+ cells originated from the embryonic epicardial cells, not from the pre-existing cardiomyocytes, endothelial cells, cardiac neural crest cells or perinatal/postnatal epicardial cells.CONCLUSION: Postnatal Nkx2.5 enhancer-expressing cells are cardiomyogenic progenitor cells and originate from embryonic epicardium-derived cells.

AB - AIM: To trace the cell origin of the cells involved in postnatal cardiomyogenesis.MATERIALS & METHODS: Nkx2.5 enhancer-eGFP (Nkx2.5 enh-eGFP) mice were used to test the cardiomyogenic potential of Nkx2.5 enhancer-expressing cells. By analyzing Cre excision of activated Nkx2.5-eGFP+ cells from different lineage-Cre/Nkx2.5 enh-eGFP/ROSA26 reporter mice, we traced the developmental origin of Nkx2.5 enhancer-expressing cells.RESULTS: Nkx2.5 enhancer-expressing cells could differentiate into striated cardiomyocytes both in vitro and in vivo. Nkx2.5-eGFP+ cells increased remarkably after experimental myocardial infarction (MI). The post-MI Nkx2.5-eGFP+ cells originated from the embryonic epicardial cells, not from the pre-existing cardiomyocytes, endothelial cells, cardiac neural crest cells or perinatal/postnatal epicardial cells.CONCLUSION: Postnatal Nkx2.5 enhancer-expressing cells are cardiomyogenic progenitor cells and originate from embryonic epicardium-derived cells.

U2 - 10.4155/fsoa-2016-0006

DO - 10.4155/fsoa-2016-0006

M3 - Article

C2 - 28031967

SN - 2056-5623

VL - 2

SP - FSO120

JO - Future Oncology

JF - Future Oncology

IS - 2

ER -

Developmental origin of postnatal cardiomyogenic progenitor cells

Abstract

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