Development of a surface-functionalized titanium implant for promoting osseointegration: Surface characteristics, hemocompatibility, and in vivo evaluation

Ping Jen Hou; Syamsiah Syam; Wen Chien Lan; Keng Liang Ou; Bai Hung Huang; Ka Chun Chan; Chi Hsun Tsai; Takashi Saito; Chung Ming Liu; Hsin Hua Chou; Yueh Tzu Huang; Fang Yu Fan

doi:10.3390/app10238582

Development of a surface-functionalized titanium implant for promoting osseointegration: Surface characteristics, hemocompatibility, and in vivo evaluation

Ping Jen Hou, Syamsiah Syam, Wen Chien Lan, Keng Liang Ou, Bai Hung Huang, Ka Chun Chan, Chi Hsun Tsai, Takashi Saito, Chung Ming Liu, Hsin Hua Chou, Yueh Tzu Huang, Fang Yu Fan

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

This study aimed to evaluate the impact of surface-modified biomedical titanium (Ti) dental implant on osseointegration. The surfaces were modified using an innovative dip-coating technique (IDCT; sandblasted, large-grit, and acid-etched, then followed by coating with the modified pluronic F127 biodegradable polymer). The surface morphology and hemocompatibility evaluations were investigated by field-emission scanning electron microscopy, while the contact analysis was observed by goniometer. The IDCT-modified Ti implant was also implanted in patients with missing teeth by single-stage surgical procedure then observed immediately and again four months after placement by cone-beam computerized tomography (CBCT) imaging. It was found that the IDCT-modified Ti implant was rougher than the dental implant without surface modification. Contact angle analysis showed the IDCT-modified Ti implant was lower than the dental implant without surface modification. The hemocompatibility evaluations showed greater red blood cell aggregation and fibrin filament formation on the IDCT-modified Ti implant. The radiographic and CBCT image displayed new bone formation at four months after the IDCT-modified Ti implant placement. Therefore, this study suggests that the IDCT-modified Ti dental implant has great potential to accelerate osseointegration.

Original language	English
Article number	8582
Pages (from-to)	1-10
Number of pages	10
Journal	Applied Sciences (Switzerland)
Volume	10
Issue number	23
DOIs	https://doi.org/10.3390/app10238582
Publication status	Published - Dec 1 2020

Keywords

Biodegradable polymer
Dental implant
Dip-coating
Osseointegration

ASJC Scopus subject areas

General Materials Science
Instrumentation
General Engineering
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes

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10.3390/app10238582

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Hou, P. J., Syam, S., Lan, W. C., Ou, K. L., Huang, B. H., Chan, K. C., Tsai, C. H., Saito, T., Liu, C. M., Chou, H. H., Huang, Y. T., & Fan, F. Y. (2020). Development of a surface-functionalized titanium implant for promoting osseointegration: Surface characteristics, hemocompatibility, and in vivo evaluation. Applied Sciences (Switzerland), 10(23), 1-10. Article 8582. https://doi.org/10.3390/app10238582

Hou, PJ, Syam, S, Lan, WC, Ou, KL, Huang, BH, Chan, KC, Tsai, CH, Saito, T, Liu, CM, Chou, HH , Huang, YT & Fan, FY 2020, 'Development of a surface-functionalized titanium implant for promoting osseointegration: Surface characteristics, hemocompatibility, and in vivo evaluation', Applied Sciences (Switzerland), vol. 10, no. 23, 8582, pp. 1-10. https://doi.org/10.3390/app10238582

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title = "Development of a surface-functionalized titanium implant for promoting osseointegration: Surface characteristics, hemocompatibility, and in vivo evaluation",

abstract = "This study aimed to evaluate the impact of surface-modified biomedical titanium (Ti) dental implant on osseointegration. The surfaces were modified using an innovative dip-coating technique (IDCT; sandblasted, large-grit, and acid-etched, then followed by coating with the modified pluronic F127 biodegradable polymer). The surface morphology and hemocompatibility evaluations were investigated by field-emission scanning electron microscopy, while the contact analysis was observed by goniometer. The IDCT-modified Ti implant was also implanted in patients with missing teeth by single-stage surgical procedure then observed immediately and again four months after placement by cone-beam computerized tomography (CBCT) imaging. It was found that the IDCT-modified Ti implant was rougher than the dental implant without surface modification. Contact angle analysis showed the IDCT-modified Ti implant was lower than the dental implant without surface modification. The hemocompatibility evaluations showed greater red blood cell aggregation and fibrin filament formation on the IDCT-modified Ti implant. The radiographic and CBCT image displayed new bone formation at four months after the IDCT-modified Ti implant placement. Therefore, this study suggests that the IDCT-modified Ti dental implant has great potential to accelerate osseointegration.",

keywords = "Biodegradable polymer, Dental implant, Dip-coating, Osseointegration",

author = "Hou, {Ping Jen} and Syamsiah Syam and Lan, {Wen Chien} and Ou, {Keng Liang} and Huang, {Bai Hung} and Chan, {Ka Chun} and Tsai, {Chi Hsun} and Takashi Saito and Liu, {Chung Ming} and Chou, {Hsin Hua} and Huang, {Yueh Tzu} and Fan, {Fang Yu}",

note = "Funding Information: The authors would like to thank the T-Plus Implant Tech. Co., Ltd. for technical support. The authors would also like to thank Dr. Chi-Chung Lo for his helpful advice and technical support on clinical evaluations examined in this paper. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

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doi = "10.3390/app10238582",

language = "English",

volume = "10",

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T2 - Surface characteristics, hemocompatibility, and in vivo evaluation

AU - Hou, Ping Jen

AU - Syam, Syamsiah

AU - Lan, Wen Chien

AU - Ou, Keng Liang

AU - Huang, Bai Hung

AU - Chan, Ka Chun

AU - Tsai, Chi Hsun

AU - Saito, Takashi

AU - Liu, Chung Ming

AU - Chou, Hsin Hua

AU - Huang, Yueh Tzu

AU - Fan, Fang Yu

N1 - Funding Information: The authors would like to thank the T-Plus Implant Tech. Co., Ltd. for technical support. The authors would also like to thank Dr. Chi-Chung Lo for his helpful advice and technical support on clinical evaluations examined in this paper. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - This study aimed to evaluate the impact of surface-modified biomedical titanium (Ti) dental implant on osseointegration. The surfaces were modified using an innovative dip-coating technique (IDCT; sandblasted, large-grit, and acid-etched, then followed by coating with the modified pluronic F127 biodegradable polymer). The surface morphology and hemocompatibility evaluations were investigated by field-emission scanning electron microscopy, while the contact analysis was observed by goniometer. The IDCT-modified Ti implant was also implanted in patients with missing teeth by single-stage surgical procedure then observed immediately and again four months after placement by cone-beam computerized tomography (CBCT) imaging. It was found that the IDCT-modified Ti implant was rougher than the dental implant without surface modification. Contact angle analysis showed the IDCT-modified Ti implant was lower than the dental implant without surface modification. The hemocompatibility evaluations showed greater red blood cell aggregation and fibrin filament formation on the IDCT-modified Ti implant. The radiographic and CBCT image displayed new bone formation at four months after the IDCT-modified Ti implant placement. Therefore, this study suggests that the IDCT-modified Ti dental implant has great potential to accelerate osseointegration.

AB - This study aimed to evaluate the impact of surface-modified biomedical titanium (Ti) dental implant on osseointegration. The surfaces were modified using an innovative dip-coating technique (IDCT; sandblasted, large-grit, and acid-etched, then followed by coating with the modified pluronic F127 biodegradable polymer). The surface morphology and hemocompatibility evaluations were investigated by field-emission scanning electron microscopy, while the contact analysis was observed by goniometer. The IDCT-modified Ti implant was also implanted in patients with missing teeth by single-stage surgical procedure then observed immediately and again four months after placement by cone-beam computerized tomography (CBCT) imaging. It was found that the IDCT-modified Ti implant was rougher than the dental implant without surface modification. Contact angle analysis showed the IDCT-modified Ti implant was lower than the dental implant without surface modification. The hemocompatibility evaluations showed greater red blood cell aggregation and fibrin filament formation on the IDCT-modified Ti implant. The radiographic and CBCT image displayed new bone formation at four months after the IDCT-modified Ti implant placement. Therefore, this study suggests that the IDCT-modified Ti dental implant has great potential to accelerate osseointegration.

KW - Biodegradable polymer

KW - Dental implant

KW - Dip-coating

KW - Osseointegration

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Development of a surface-functionalized titanium implant for promoting osseointegration: Surface characteristics, hemocompatibility, and in vivo evaluation

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