Development and Regeneration of Muscle, Tendon and Myotendinous Junctions in Striated Skeletal Muscle

Masahito Yamamoto, Koji Sakiyama, Kei Kitamura, Yutaro Yamamoto, Takahiro Takagi, Sayo Sekiya, Genji Watanabe, Shuichiro Taniguchi, Yudai Ogawa, Satoshi Ishizuka, Yuki Sugiyama, Takeshi Takayama, Katsuhiko Hayashi, Wei Jen Chang, Shinichi Abe

Research output: Contribution to journalReview articlepeer-review


Owing to a rapid increase in aging population in recent years, the deterioration of motor function in older adults has become an important social problem, and several studies have aimed to investigate the mechanisms underlying muscle function decline. Furthermore, structural maintenance of the muscle–tendon–bone complexes in the muscle attachment sites is important for motor function, particularly for joints; however, the development and regeneration of these complexes have not been studied thoroughly and require further elucidation. Recent studies have provided insights into the roles of mesenchymal progenitors in the development and regeneration of muscles and myotendinous junctions. In particular, studies on muscles and myotendinous junctions have—through the use of the recently developed scRNA‐seq—reported the presence of syncytia, thereby suggesting that fibroblasts may be transformed into myoblasts in a BMP-dependent manner. In addition, the high mobility group box 1—a DNA‐binding protein found in nuclei—is reportedly involved in muscle regeneration. Furthermore, studies have identified several factors required for the formation of locomotor apparatuses, e.g., tenomodulin (Tnmd) and mohawk (Mkx), which are essential for tendon maturation.

Original languageEnglish
Article number3006
JournalInternational journal of molecular sciences
Issue number6
Publication statusPublished - Mar 1 2022


  • HMGB1 protein
  • Myoblasts
  • Single‐cell analysis
  • Skeletal muscle
  • Small cytoplasmic RNA
  • Staphylococcal protein A

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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