TY - JOUR
T1 - Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway
AU - Wakabayashi, Grace
AU - Lee, Yu Ching
AU - Luh, Frank
AU - Kuo, Chun Nan
AU - Chang, Wei Chao
AU - Yen, Yun
N1 - Funding Information:
This work was financially supported by the TMU Research Center of Cancer Translational Medicine from the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan.
PY - 2019/12/5
Y1 - 2019/12/5
N2 - Dramatic advances in immune therapy have emerged as a promising strategy in cancer therapeutics. In addition to chemotherapy and radiotherapy, inhibitors targeting immune-checkpoint molecules such as cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed cell death receptor-1 (PD-1) and its ligand (PD-L1) demonstrate impressive clinical benefits in clinical trials. In this review, we present background information about therapies involving PD-1/PD-L1 blockade and provide an overview of current clinical trials. Furthermore, we present recent advances involving predictive biomarkers associated with positive therapeutic outcomes in cancer immunotherapy.
AB - Dramatic advances in immune therapy have emerged as a promising strategy in cancer therapeutics. In addition to chemotherapy and radiotherapy, inhibitors targeting immune-checkpoint molecules such as cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed cell death receptor-1 (PD-1) and its ligand (PD-L1) demonstrate impressive clinical benefits in clinical trials. In this review, we present background information about therapies involving PD-1/PD-L1 blockade and provide an overview of current clinical trials. Furthermore, we present recent advances involving predictive biomarkers associated with positive therapeutic outcomes in cancer immunotherapy.
KW - Cancer immunotherapy
KW - Checkpoint inhibitor
KW - PD-1 PD-L1 signaling
UR - http://www.scopus.com/inward/record.url?scp=85075998495&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075998495&partnerID=8YFLogxK
U2 - 10.1186/s12929-019-0588-8
DO - 10.1186/s12929-019-0588-8
M3 - Review article
C2 - 31801525
AN - SCOPUS:85075998495
SN - 1021-7770
VL - 26
JO - Journal of Biomedical Science
JF - Journal of Biomedical Science
IS - 1
M1 - 96
ER -
