Development and biocompatibility tests of electrospun poly-l-lactide nanofibrous membranes incorporating oleic acid-coated Fe3O 4

The aim of this study was to develop an electrospun poly-l-lactide (PLLA) nanofibrous membrane incorporating oleic acid-coated Fe₃O ₄. The Fe₃O₄ nanoparticles were prepared using the chemical co-precipitation method, and particle diameters were analyzed using transmission electron microscopy. After mixing the oleic acid-coated Fe ₃O₄ nanoparticles and PLLA, a membrane with nanofibers was manufactured using the electrospinning technique. Our results showed that Fe₃O₄ nanoparticle diameters fabricated in this study were concentrated at 2-8 nm (84.2%). After magnetizing, there exists an approximately linear relationship between magnetic flux density and membrane thickness (R²=0.7, p3O₄/PLLA nanomembranes exhibited a more spreading and attached phenotype. These results can serve as a reference for future advanced studies.