Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.
- Drug design
- Optical tweezers
- Radiation therapy
- Single-molecule studies
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Physical and Theoretical Chemistry