Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

Tzu Sen Yang; Yujia Cui; Chien Ming Wu; Jem Mau Lo; Chi Shiun Chiang; Wun Yi Shu; Wei Ju Chung; Chung Shan Yu; Kuo Ning Chiang; Lan C. Hsu

doi:10.1002/cphc.200900435

Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

Tzu Sen Yang, Yujia Cui, Chien Ming Wu, Jem Mau Lo, Chi Shiun Chiang, Wun Yi Shu, Wei Ju Chung, Chung Shan Yu, Kuo Ning Chiang, Lan C. Hsu

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.

Original language	English
Pages (from-to)	2791-2794
Number of pages	4
Journal	ChemPhysChem
Volume	10
Issue number	16
DOIs	https://doi.org/10.1002/cphc.200900435
Publication status	Published - Nov 9 2009

Keywords

DNA
Drug design
Optical tweezers
Radiation therapy
Single-molecule studies

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Physical and Theoretical Chemistry

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10.1002/cphc.200900435

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title = "Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach",

abstract = "Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.",

keywords = "DNA, Drug design, Optical tweezers, Radiation therapy, Single-molecule studies",

author = "Yang, {Tzu Sen} and Yujia Cui and Wu, {Chien Ming} and Lo, {Jem Mau} and Chiang, {Chi Shiun} and Shu, {Wun Yi} and Chung, {Wei Ju} and Yu, {Chung Shan} and Chiang, {Kuo Ning} and Hsu, {Lan C.}",

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AU - Yang, Tzu Sen

AU - Cui, Yujia

AU - Wu, Chien Ming

AU - Lo, Jem Mau

AU - Chiang, Chi Shiun

AU - Shu, Wun Yi

AU - Chung, Wei Ju

AU - Yu, Chung Shan

AU - Chiang, Kuo Ning

AU - Hsu, Lan C.

PY - 2009/11/9

Y1 - 2009/11/9

N2 - Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.

AB - Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.

KW - DNA

KW - Drug design

KW - Optical tweezers

KW - Radiation therapy

KW - Single-molecule studies

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Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

Abstract

Keywords

ASJC Scopus subject areas

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