Determinants of the creatinine clearance to glomerular filtration rate ratio in patients with chronic kidney disease: A cross-sectional study

Yen Chung Lin; Nisha Bansal; Eric Vittinghoff; Alan S. Go; Chi Yuan Hsu

doi:10.1186/1471-2369-14-268

Determinants of the creatinine clearance to glomerular filtration rate ratio in patients with chronic kidney disease: A cross-sectional study

Yen Chung Lin, Nisha Bansal, Eric Vittinghoff, Alan S. Go, Chi Yuan Hsu

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Background: Creatinine secretion, as quantified by the ratio of creatinine clearance (CrCl) to glomerular filtration rate (GFR), may introduce another source of error when using serum creatinine concentration to estimate GFR. Few studies have examined determinants of the CrCl/GFR ratio. We sought to study whether higher levels of albuminuria would be associated with higher, and being non-Hispanic black with lower, CrCl/GFR ratio. Methods. We did a cross-sectional analysis of 1342 patients with chronic kidney disease from the Chronic Renal Insufficiency Cohort (CRIC) who had baseline measure of iothalamate GFR (iGFR) and 24-hour urine collections. Our predictors included urine albumin as determined from 24-hour urine collections (categorized as:

Original language	English
Article number	268
Journal	BMC Nephrology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/1471-2369-14-268
Publication status	Published - Dec 5 2013

Keywords

Albuminuria
Chronic kidney disease
Glomerular filtration rate
Race/Ethnicity

ASJC Scopus subject areas

Nephrology

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10.1186/1471-2369-14-268

Cite this

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abstract = "Background: Creatinine secretion, as quantified by the ratio of creatinine clearance (CrCl) to glomerular filtration rate (GFR), may introduce another source of error when using serum creatinine concentration to estimate GFR. Few studies have examined determinants of the CrCl/GFR ratio. We sought to study whether higher levels of albuminuria would be associated with higher, and being non-Hispanic black with lower, CrCl/GFR ratio. Methods. We did a cross-sectional analysis of 1342 patients with chronic kidney disease from the Chronic Renal Insufficiency Cohort (CRIC) who had baseline measure of iothalamate GFR (iGFR) and 24-hour urine collections. Our predictors included urine albumin as determined from 24-hour urine collections (categorized as: ",

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T1 - Determinants of the creatinine clearance to glomerular filtration rate ratio in patients with chronic kidney disease

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AU - Lin, Yen Chung

AU - Bansal, Nisha

AU - Vittinghoff, Eric

AU - Go, Alan S.

AU - Hsu, Chi Yuan

PY - 2013/12/5

Y1 - 2013/12/5

N2 - Background: Creatinine secretion, as quantified by the ratio of creatinine clearance (CrCl) to glomerular filtration rate (GFR), may introduce another source of error when using serum creatinine concentration to estimate GFR. Few studies have examined determinants of the CrCl/GFR ratio. We sought to study whether higher levels of albuminuria would be associated with higher, and being non-Hispanic black with lower, CrCl/GFR ratio. Methods. We did a cross-sectional analysis of 1342 patients with chronic kidney disease from the Chronic Renal Insufficiency Cohort (CRIC) who had baseline measure of iothalamate GFR (iGFR) and 24-hour urine collections. Our predictors included urine albumin as determined from 24-hour urine collections (categorized as:

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KW - Glomerular filtration rate

KW - Race/Ethnicity

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Determinants of the creatinine clearance to glomerular filtration rate ratio in patients with chronic kidney disease: A cross-sectional study

Abstract

Keywords

ASJC Scopus subject areas

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