Detection of C-reactive protein based on measurement of Brownian motion by micro-particle-tracking-velocimetry

Y. J. Fan; Chiajui Hsu; Chengpang Liu; Tzuheng Wu; Horn Jiunn Sheen; Shyhfeng Lin

doi:10.1109/MEMSYS.2008.4443625

Detection of C-reactive protein based on measurement of Brownian motion by micro-particle-tracking-velocimetry

Y. J. Fan, Chiajui Hsu, Chengpang Liu, Tzuheng Wu, Horn Jiunn Sheen, Shyhfeng Lin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

A novel bio-sensing technique based on Brownian motion change with use of a micro-particle-tracking-velocimetry (micro-PTV) has been successfully developed to measure the antigen-antibody interactions. The rapid interaction between antigen, C-reactive protein (CRP), and the nanobeads conjugated with antibody, anti-CRP, enabled the real-time detection of CRP to be easily carried out. During the binding process of nanobeads to CRP, the mean value of the beads diameter increased so that the Brownian velocity decreased with increasing time. Moreover, higher CRP concentration led to lower Brownian velocity of the nanobead at equilibrium state. Furthermore, the sensitivity was raised when the smaller nanobeads were used.

Original language	English
Title of host publication	MEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems
Pages	192-195
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2008.4443625
Publication status	Published - 2008
Externally published	Yes
Event	21st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2008 Tucson - Tucson, AZ, United States Duration: Jan 13 2008 → Jan 17 2008

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Conference

Conference	21st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2008 Tucson
Country/Territory	United States
City	Tucson, AZ
Period	1/13/08 → 1/17/08

ASJC Scopus subject areas

Mechanical Engineering
Electrical and Electronic Engineering
Control and Systems Engineering

Access to Document

10.1109/MEMSYS.2008.4443625

Cite this

Fan, Y. J., Hsu, C., Liu, C., Wu, T., Sheen, H. J., & Lin, S. (2008). Detection of C-reactive protein based on measurement of Brownian motion by micro-particle-tracking-velocimetry. In MEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems (pp. 192-195). Article 4443625 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2008.4443625

Detection of C-reactive protein based on measurement of Brownian motion by micro-particle-tracking-velocimetry. / Fan, Y. J.; Hsu, Chiajui; Liu, Chengpang et al.
MEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems. 2008. p. 192-195 4443625 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Fan, YJ, Hsu, C, Liu, C, Wu, T, Sheen, HJ & Lin, S 2008, Detection of C-reactive protein based on measurement of Brownian motion by micro-particle-tracking-velocimetry. in MEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems., 4443625, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 192-195, 21st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2008 Tucson, Tucson, AZ, United States, 1/13/08. https://doi.org/10.1109/MEMSYS.2008.4443625

Fan YJ, Hsu C, Liu C, Wu T, Sheen HJ, Lin S. Detection of C-reactive protein based on measurement of Brownian motion by micro-particle-tracking-velocimetry. In MEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems. 2008. p. 192-195. 4443625. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2008.4443625

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abstract = "A novel bio-sensing technique based on Brownian motion change with use of a micro-particle-tracking-velocimetry (micro-PTV) has been successfully developed to measure the antigen-antibody interactions. The rapid interaction between antigen, C-reactive protein (CRP), and the nanobeads conjugated with antibody, anti-CRP, enabled the real-time detection of CRP to be easily carried out. During the binding process of nanobeads to CRP, the mean value of the beads diameter increased so that the Brownian velocity decreased with increasing time. Moreover, higher CRP concentration led to lower Brownian velocity of the nanobead at equilibrium state. Furthermore, the sensitivity was raised when the smaller nanobeads were used.",

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Detection of C-reactive protein based on measurement of Brownian motion by micro-particle-tracking-velocimetry

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