TY - JOUR
T1 - Dementia Risk in Irradiated Patients with Head and Neck Cancer
AU - Chen, Jin-Hua
AU - Yen, Yu-Chun
AU - Liu, Shing Hwa
AU - Lee, Fei-Peng
AU - Lin, Kuan Chou
AU - Lai, Ming-Tang
AU - Wu, Chia-Che
AU - Chen, Tsung Ming
AU - Yuan, Sheng Po
AU - Chang, Chia Lun
AU - Wu, Szu-Yuan
N1 - Export Date: 29 March 2016
CODEN: MEDIA
通訊地址: Wu, S.-Y.; Taipei Medical University, Institute of Toxicology, College of Medicine, Hsing-Long Rd, Taiwan; 電子郵件： [email protected]
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PY - 2015
Y1 - 2015
N2 - Patients with head and neck cancer are treated through surgery, radiotherapy (RT), and chemotherapy (CT). Carotid artery damage and neurotoxicity were previously observed in these patients. This study estimated the dementia risk associated with different treatment modalities in a head and neck cancer population with long-term follow-up. Taiwan's National Health Insurance claims database and a cancer registry database from the Collaboration Center of Health Information Application were linked for the present analysis. Patients with head and neck cancer, treated from January 1, 2002 to December 31, 2010, were included in the study. The follow-up duration was the period from the index date to December 31, 2012. Inclusion criteria were head and neck cancer; an age >20 years; and having undergone surgery, CT, concurrent CT, or surgery with adjuvant treatment. Exclusion criteria were another cancer diagnosed before the head and neck cancer, death or being diagnosed with dementia within 2 years after the treatment of the head and neck cancer, stroke before the index date, distant metastasis, in situ carcinoma, sarcoma, head and neck cancer recurrence, an unknown sex, and an age 65 years and having undergone RT with or without CT were risk factors (P6660 cGy exhibited a 1.69-fold (95% CI 0.97-2.95, P=0.063) higher dementia risk compared with those who received a total radiation dose
AB - Patients with head and neck cancer are treated through surgery, radiotherapy (RT), and chemotherapy (CT). Carotid artery damage and neurotoxicity were previously observed in these patients. This study estimated the dementia risk associated with different treatment modalities in a head and neck cancer population with long-term follow-up. Taiwan's National Health Insurance claims database and a cancer registry database from the Collaboration Center of Health Information Application were linked for the present analysis. Patients with head and neck cancer, treated from January 1, 2002 to December 31, 2010, were included in the study. The follow-up duration was the period from the index date to December 31, 2012. Inclusion criteria were head and neck cancer; an age >20 years; and having undergone surgery, CT, concurrent CT, or surgery with adjuvant treatment. Exclusion criteria were another cancer diagnosed before the head and neck cancer, death or being diagnosed with dementia within 2 years after the treatment of the head and neck cancer, stroke before the index date, distant metastasis, in situ carcinoma, sarcoma, head and neck cancer recurrence, an unknown sex, and an age 65 years and having undergone RT with or without CT were risk factors (P6660 cGy exhibited a 1.69-fold (95% CI 0.97-2.95, P=0.063) higher dementia risk compared with those who received a total radiation dose
U2 - 10.1097/MD.0000000000001983
DO - 10.1097/MD.0000000000001983
M3 - Article
C2 - 26559280
SN - 0025-7974
VL - 94
SP - e1983
JO - Medicine (United States)
JF - Medicine (United States)
IS - 45
ER -
