Deformability of mice erythrocytes measured by oscillatory optical tweezers

Yu Shan Huang, Chia Lun Yeh, Guan Bo Liao, Yi Fan Chen, Ting Fen Tsai, Arthur Chiou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


We used one-dimensional oscillatory optical tweezers in a discrete scanning (or jumping) mode to trap and stretch individual mice erythrocytes and measured their deformation as a function of the jumping distance of the oscillatory trapping beam. In general, we observed that the length of the long axis of red blood cells (RBCs) decreased slightly at small jumping distance and then increased after the jumping distance exceeded a threshold value on the order of a few microns, which is consistent with a recent theoretical prediction. The deformability of three types of mice RBCs, namely the wide-type mice (serving as the control group), old mice, and gene knockout mice were measured and compared. Statistical analysis of their deformability reveals that the RBCs of old mice can be distinguished from those of knockout mice even though these two types of mice exhibit many similar aging-like features.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 2008
Externally publishedYes
EventOptical Trapping and Optical Micromanipulation V - San Diego, CA, United States
Duration: Aug 10 2008Aug 13 2008


OtherOptical Trapping and Optical Micromanipulation V
Country/TerritoryUnited States
CitySan Diego, CA


  • Erythrocyte
  • Gene knockout
  • Oscillatory optical tweezers

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics


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