TY - JOUR
T1 - Definitive intensity-modulated radiotherapy or surgery for early oral cavity squamous cell carcinoma
T2 - Propensity-score-matched, nationwide, population-based cohort study
AU - Liu, Wen Chi
AU - Liu, Hsueh Erh
AU - Kao, Yi Wei
AU - Qin, Lei
AU - Lin, Kuan Chou
AU - Fang, Chih Yuan
AU - Tsai, Lo Lin
AU - Shia, Ben Chang
AU - Wu, Szu Yuan
N1 - Funding Information:
Lo‐Hsu Medical Foundation, Lotung Poh‐Ai Hospital, supports Szu‐Yuan Wu's work (Funding Number: 10908 and 10 909). Ben‐Chang Shia's work was also supported by an institutional grant from Taipei Medical University (Taipei, Taiwan) for New Faculty Research (TMU103‐AE1‐B22).
Publisher Copyright:
© 2020 Wiley Periodicals LLC
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - Background: No evidence is currently available to estimate the outcomes of intensity-modulated radiation therapy (IMRT) and surgery for patients with early oral cavity squamous cell carcinoma (E-OCSCC). Methods: We recruited patients from the Taiwan Cancer Registry Database who had received a diagnosis of E-OCSCC. Propensity score matching was performed, and Cox proportional hazards model was used to analyze all-cause mortality. Results: In the multivariate Cox regression analyses, the adjusted hazard ratio (aHR) (95% confidence interval [CI]) for surgery compared with definitive IMRT, T2N0M0 compared with T1N0M0, and male patients compared with female patients were 0.303 (0.245, 0.375), 1.340 (1.077, 1.668), and 2.012 (1.432, 2.826), respectively. The aHRs (95% CIs) for age 61 to 70, 71 to 80, and ≧81 years compared with <40 years were 2.984 (1.43, 4.225), 3.353 (2.578, 4.112), and 4.277 (4.104, 5.679), respectively. Conclusions: For patients with E-OCSCC, surgery may be considered the first option rather than definitive IMRT.
AB - Background: No evidence is currently available to estimate the outcomes of intensity-modulated radiation therapy (IMRT) and surgery for patients with early oral cavity squamous cell carcinoma (E-OCSCC). Methods: We recruited patients from the Taiwan Cancer Registry Database who had received a diagnosis of E-OCSCC. Propensity score matching was performed, and Cox proportional hazards model was used to analyze all-cause mortality. Results: In the multivariate Cox regression analyses, the adjusted hazard ratio (aHR) (95% confidence interval [CI]) for surgery compared with definitive IMRT, T2N0M0 compared with T1N0M0, and male patients compared with female patients were 0.303 (0.245, 0.375), 1.340 (1.077, 1.668), and 2.012 (1.432, 2.826), respectively. The aHRs (95% CIs) for age 61 to 70, 71 to 80, and ≧81 years compared with <40 years were 2.984 (1.43, 4.225), 3.353 (2.578, 4.112), and 4.277 (4.104, 5.679), respectively. Conclusions: For patients with E-OCSCC, surgery may be considered the first option rather than definitive IMRT.
KW - early stage
KW - intensity-modulated radiation therapy
KW - oral cavity squamous cell carcinoma
KW - surgery
KW - survival
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U2 - 10.1002/hed.26575
DO - 10.1002/hed.26575
M3 - Article
AN - SCOPUS:85097395632
SN - 1043-3074
VL - 43
SP - 1142
EP - 1152
JO - Head and Neck Surgery
JF - Head and Neck Surgery
IS - 4
ER -
