Defect-passivated metal halide perovskite quantum dots stabilized into biodegradable porous polydopamine nanoparticles for photothermal/chemodynamic/gas therapy of cancer

Girum Getachew, Ying Chih Tien, Tzu Chun Kan, Worku Batu Dirersa, Aswandi Wibrianto, Sonjid Orchirbat, Jungshan Chang, Akash S. Rasal, Vivek Gurav, Shamsa Kizhepat, Jia Yaw Chang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Herein, we reported a one-pot synthesis of CsPbBr3 quantum dots (QDs) passivated with diammonium sulfide (NH4)2S additive using the probe-sonication technique. (NH4)2S-treated CsPbBr3 (NS-CsPbBr3) QDs exhibited superior optical properties compared to untreated QDs. The aqueous stability of NS-CsPbBr3 QDs was improved by physical loading into porous manganese (Mn)-enriched polydopamine nanoparticles (mPDA NPs) via physical adsorption strategy, followed by functionalization with folic acid (FA), resulting in multifunctional nanospheres (denoted as NCPB@mPDA/FA NSs). The Mn2+ and S2- ions in the NCPB@mPDA/FA NSs generated cytotoxic •OH radicals for chemodynamic treatment (CDT) and H2S gas for gas therapy (GT) under acidic conditions, respectively. Furthermore, the intracellular antioxidant glutathione was significantly blocked using NCPB@mPDA/FA for enhanced CDT efficiency. Upon 808 nm laser irradiation, the green-emitting NCPB@mPDA/FA NSs demonstrated not only outstanding photothermal therapy (Ƞ=41.5%) due to considerable absorption in the near-infrared range but also stimulated the release of Mn2+ and S2- ions for photothermal-triggered CDT and GT of cancer. The cancer cells effectively internalized NCPB@mPDA/FA through CD44 folate receptors, leading to a bright cellular image. Additionally, when combined with laser and H2O2, NCPB@mPDA/FA exhibited significant effectiveness against HeLa and 4T1 cells. Upon intravenous administration, NCPB@mPDA/FA exhibited notable tumor accumulation, resulting in enhanced tumor suppression in vivo, attributed to the improved hyperthermia-induced CDT and GT. The in vivo tumor inhibition potential of perovskite QD-based materials was demonstrated for the first time, indicating their therapeutic capabilities.

Original languageEnglish
Article number143560
JournalChemical Engineering Journal
Volume467
DOIs
Publication statusPublished - Jul 1 2023

Keywords

  • Cellular image
  • Chemodynamic therapy
  • Gas therapy
  • Photothermal therapy
  • Quantum dots

ASJC Scopus subject areas

  • General Chemistry
  • Environmental Chemistry
  • General Chemical Engineering
  • Industrial and Manufacturing Engineering

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