TY - JOUR
T1 - Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: A 20-year follow-up study
AU - Chang, Mei-Hwei
AU - You, San-Lin
AU - Chen, Chien-Jen
AU - Liu, Chun-Jen
AU - Lee, Chuan-Mo
AU - Lin, Shi-Ming
AU - Chu, Heng-Cheng
AU - Wu, Tzee-Chung
AU - Yang, Sheng-Shun
AU - Kuo, Hsu-Sung
AU - Chen, Ding-Shinn
N1 - 被引用次數：249
Export Date: 22 March 2016
CODEN: JNCIA
通訊地址: Chang, M.-H.; Department of Pediatrics, College of Public Health, National Taiwan University, Chung-Shan S. Road, Taipei, Taiwan; 電子郵件： [email protected]
化學物質/CAS: Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B e Antigens
參考文獻: Larouze, B., Saimot, G., Lustbader, E.D., London, W.T., Werner, B.G., Payet, M., Host response to hepatitis B infection in patients with primary hepatic carcinoma and their families: A case control study in Senegal West Africa Lancet, 2 (7985), pp. 534-538; Beasley, R.P., Hwang, L.Y., Lin, C.C., Chien, C.S., Hepatocellular carcinoma and hepatitis B virus: A prospective study of 22,707 men in Taiwan (1981) Lancet, 2 (8256), pp. 1129-1133; Popper, H., Ma, G., Thung, S.N., The relation of hepatocellular carcinoma to infection with hepatitis B and related viruses in man and animals (1982) Hepatology, 2 (SUPPL.), pp. 1S-9S; Chen, D.S., Hepatitis B virus infection, its sequelae, and prevention in Taiwan (1987) Neoplasms of the Liver, pp. 71-80. , Okuda K, Ishak G, eds Tokyo, Japan : Springer-Verlag; Lee, C.M., Lu, S.N., Changchien, C.S., Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection (1999) Cancer, 86 (7), pp. 1143-1150; Chang, M.H., Chen, D.S., Hsu, H.C., Hsu, H.Y., Lee, C.Y., Maternal transmission of hepatitis B virus in childhood hepatocellular carcinoma (1989) Cancer, 64 (11), pp. 2377-2380; Chang, M.H., Chen, P.J., Chen, J.Y., Hepatitis B virus integration in hepatitis B virus-related hepatocellular carcinoma in childhood (1991) Hepatology, 13 (2), pp. 316-320; Chen, D.S., Hsu, N.H., Sung, J.L., A mass vaccination program in Taiwan against hepatitis B virus infection in infants of hepatitis B surface antigen-carrier mothers (1987) JAMA, 257 (19), pp. 2597-2603; Ni, Y.H., Chang, M.H., Huang, L.M., Hepatitis B virus infection in children and adolescents in a hyperendemic area: 15 years after universal hepatitis B vaccination (2001) Ann Intern Med, 135 (9), pp. 769-800; Chang, M.H., Chen, C.J., Lai, M.S., Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children (1997) N Engl J Med, 336 (26), pp. 1855-1859; Chang, M.H., Chen, T., Hsu, H.M., Problems in the prevention of childhood hepatocellular carcinoma in the era of universal hepatitis B immunization (2005) Clin Cancer Res., 11 (21), pp. 7953-7957; Bosch, F.X., Ribes, J., The epidemiology of primary liver cancer: Global epidemiology (2002) Viruses and Liver Cancer, pp. 1-16. , Tabor E, ed Amsterdam, the Netherlands : Elsevier; Ni, Y.H., Chang, M.H., Hsu, H.Y., Hepatocellular carcinoma in childhood: Clinical manifestations and prognosis (1991) Cancer, 68 (8), pp. 1737-1741; Kuo, C.Y., Liu, H.C., Chang, M.H., Hepatoblastoma in infancy and childhood: A clinical and pathological study of 32 cases (1991) Acta Paediatr Taiwan, 32 (2), pp. 79-87; (2008) Cancer Registry Annual Report 2005, , Bureau of Health Promotion (ROC) Taipei, Taiwan : Bureau of Health Promotion; Chen, C.N., Liu, P.K.C., An evaluation of Taiwan Census 2000: A comparison of census and registered populations (2002) J Popul Stud, 25 (1), pp. 1-56; Ni, Y.H., Huang, L.M., Chang, M.H., Two decades of universal hepatitis B vaccination in Taiwan: Impact and implication for future strategies (2007) Gastroenterology, 132 (4), pp. 1287-1293; Breslow, N.F., Day, N.E., Statistical methods in cancer research II: The design and analysis of cohort studies (1987) Fitting Models to Group Data, pp. 121-176. , Breslow NF, Day NE, eds Lyon : France International Agency for Research on Cancer (IARC) Scientifi c Publications No.82; Tang, J.R., Hsu, H.Y., Lin, H.H., Ni, Y.H., Chang, M.H., Hepatitis B surface antigenemia at birth: A long-term follow-up study (1998) J Pediatr, 133 (3), pp. 374-1137; Blonski, W., Reddy, K.R., Hepatitis C virus infection and hepatocellular carcinoma (2008) Clin Liver Dis, 12 (3), pp. 661-674; Chang, M.H., Lee, C.Y., Chen, D.S., Minimal role of hepatitis C virus infection in childhood liver diseases in an area hyperendemic for hepatitis B infection (1993) J Med Virol, 40 (4), pp. 322-325; Wang, L.Y., You, S.L., Lu, S.N., Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: A cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in Taiwan (2003) Cancer Causes Control, 14 (3), pp. 241-250; Kuper, H., Ye, W., Broom, U., The risk of liver and bile duct cancer in patients with chronic viral hepatitis, alcoholism, or cirrhosis (2001) Hepatology, 34 (4), pp. 714-718; Gouas, D., Shi, H., Hainaut, P., The afl atoxin-induced TP53 mutation at codon 249 (R249S): Biomarker of exposure, early detection and target for therapy (2009) Cancer Lett, , doi:10.1016/j.canlet.2009.02.057; Chou, S.Y., Lee, M.P., Liang, M., Prevalence of smoking, alcohol consumption, betal nut chewing and illicit drug use among adolescents in Taiwan (2006) Mid Taiwan J Med, 11 (3), pp. 177-186; Sheu, J.C., Huang, G.T., Lee, P.H., Mutation of p53 gene in hepatocel-lular carcinoma in Taiwan (1992) Cancer Res, 52 (21), pp. 6098-6100
PY - 2009
Y1 - 2009
N2 - Background Hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma. This population-based study aimed to investigate whether prevention of hepatocellular carcinoma by the universal Taiwanese HBV vaccine program, launched in July 1984, has extended beyond childhood and to identify the predictors of hepatocellular carcinoma for vaccinated birth cohorts.MethodsData on 1958 patients with hepatocellular carcinoma who were aged 6-29 years at diagnosis in Taiwan between 1983 and 2004 were collected from two national hepatocellular carcinoma registries. Age-and sex-specific incidence among vaccinated and unvaccinated birth cohorts were analyzed by using Poisson regression models. All statistical tests were two-sided. Records of 64 hepatocellular carcinoma patients and 5524435 HBV vaccinees who were born after the initiation of the vaccination program were compared for HBV immunization characteristics during infancy and prenatal maternal hepatitis B surface antigen (HBsAg) and e antigen (HBeAg) serostatus.ResultsHepatocellular carcinoma incidence was statistically significantly lower among children aged 6-19 years in vaccinated compared with unvaccinated birth cohorts (64 hepatocellular cancers among vaccinees in 37709304 person-years vs 444 cancers in unvaccinated subjects in 78496406 person-years, showing an age-and sex-adjusted relative risk of 0.31, P
AB - Background Hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma. This population-based study aimed to investigate whether prevention of hepatocellular carcinoma by the universal Taiwanese HBV vaccine program, launched in July 1984, has extended beyond childhood and to identify the predictors of hepatocellular carcinoma for vaccinated birth cohorts.MethodsData on 1958 patients with hepatocellular carcinoma who were aged 6-29 years at diagnosis in Taiwan between 1983 and 2004 were collected from two national hepatocellular carcinoma registries. Age-and sex-specific incidence among vaccinated and unvaccinated birth cohorts were analyzed by using Poisson regression models. All statistical tests were two-sided. Records of 64 hepatocellular carcinoma patients and 5524435 HBV vaccinees who were born after the initiation of the vaccination program were compared for HBV immunization characteristics during infancy and prenatal maternal hepatitis B surface antigen (HBsAg) and e antigen (HBeAg) serostatus.ResultsHepatocellular carcinoma incidence was statistically significantly lower among children aged 6-19 years in vaccinated compared with unvaccinated birth cohorts (64 hepatocellular cancers among vaccinees in 37709304 person-years vs 444 cancers in unvaccinated subjects in 78496406 person-years, showing an age-and sex-adjusted relative risk of 0.31, P
KW - hepatitis B surface antigen
KW - hepatitis B vaccine
KW - hepatitis B(e) antigen
KW - adult
KW - article
KW - child
KW - controlled study
KW - female
KW - follow up
KW - health program
KW - hepatitis B
KW - human
KW - incidence
KW - liver cell carcinoma
KW - major clinical study
KW - male
KW - perinatal infection
KW - preschool child
KW - priority journal
KW - risk factor
KW - sex difference
KW - Taiwan
KW - Adolescent
KW - Adult
KW - Age Distribution
KW - Carcinoma, Hepatocellular
KW - Child
KW - Female
KW - Follow-Up Studies
KW - Hepatitis B e Antigens
KW - Hepatitis B Surface Antigens
KW - Hepatitis B Vaccines
KW - Humans
KW - Incidence
KW - Liver Neoplasms
KW - Male
KW - Mothers
KW - Multivariate Analysis
KW - Odds Ratio
KW - Registries
KW - Sex Distribution
KW - Young Adult
U2 - 10.1093/jnci/djp288
DO - 10.1093/jnci/djp288
M3 - Article
SN - 0027-8874
VL - 101
SP - 1348
EP - 1355
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 19
ER -
