Decreased cardiac vagal control in drug-naïve patients with posttraumatic stress disorder

Hsin An Chang, Chuan Chia Chang, Nian Sheng Tzeng, Terry B J Kuo, Ru Band Lu, San Yuan Huang

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Objective Decreased cardiac vagal control (CVC) has been proposed in posttraumatic stress disorder (PTSD), but the results are mixed. Analyses with larger sample sizes and better methodology are needed. Methods Thirty-two drug-naïve survivors with current PTSD, 32 survivors without PTSD and 192 matched controls were recruited for a case-control analysis. We used the PTSD checklist-civilian version (PCL-C) to assess posttraumatic symptoms severity. Cardiac autonomic function was evaluated by measuring heart rate variability (HRV) parameters. Frequency-domain indices of HRV were obtained. The obtained results were evaluated in association with personality traits assessed by the Tridimensional Personality Questionnaire (TPQ). Results PTSD patients exhibited decreased LF-HRV and HF-HRV as compared to survivors without PTSD and to matched controls. The PTSD symptoms severity was associated with reduced mean RR intervals, Var-HRV, LF-HRV and HF-HRV. The harm avoidance score (which has been suggested to be associated with serotonergic activity) was negatively correlated with Var-HRV, LF-HRV and HF-HRV. Conclusion These data suggest that PTSD is accompanied by decreased CVC, highlighting the importance of assessing HRV in PTSD patients. In view of the increased risk for cardiovascular diseases in these vulnerable individuals, one might consider the treatment to restore their autonomic function while reducing PTSD symptoms.

Original languageEnglish
Pages (from-to)121-130
Number of pages10
JournalPsychiatry Investigation
Issue number2
Publication statusPublished - Jun 2013
Externally publishedYes


  • Cardiac autonomic function
  • Heart rate variability
  • Posttraumatic stress disorder
  • Vagal control

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'Decreased cardiac vagal control in drug-naïve patients with posttraumatic stress disorder'. Together they form a unique fingerprint.

Cite this