Abstract
OBJECTIVE: Our purpose was to verify regional immune modulations and to test the effect of gonadotropin-releasing hormone agonist in women with endometriosis. STUDY DESIGN: Concentrations of peritoneal cytokines, including interleukin-1β interleukin-2, soluble interleukin-2 receptor, interleukin-6, granulocyte-monocyte colony-stimulating factor, interferon gamma, and tumor necrosis factor-α were compared in women with and without endometriosis. Peritoneal cytokine and interleukin-2 production were examined by adding various mitogens to peritoneal fluid mononuclear cells of women with advanced endometriosis before and after gonadotropin-releasing hormone agonist treatment. RESULTS: A significant increase in peritoneal interleukin- 1β interleukin-6, and tumor necrosis factor-α and a decrease in interferon gamma were noted in women with endometriosis. After gonadotropin-releasing hormone agonist treatment interleukin-6 decreased and interferon gamma increased. A significant impairment of interleukin-2 production of peritoneal fluid mononuclear cells by phytohemagglutinin and pokeweed mitogen stimulation was demonstrated in endometriosis, and production could be restored after gonadotropin-releasing hormone agonist treatment. CONCLUSION: These results indicate that regional immunologic dysfunction might be invoked in the disease process of endometriosis.
Original language | English |
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Pages (from-to) | 1236-1241 |
Number of pages | 6 |
Journal | American Journal of Obstetrics and Gynecology |
Volume | 175 |
Issue number | 5 |
DOIs | |
Publication status | Published - Jan 1 1996 |
Externally published | Yes |
Keywords
- Endometriosis
- gonadotropin-releasing hormone agonist
- interferon gamma
- interleukin-6
- T-cell activation
ASJC Scopus subject areas
- Obstetrics and Gynaecology