Cytotoxic steroidal saponins from Agave sisalana

Pi Yu Chen; Chin Hui Chen; Ching Chuan Kuo; Zong-Huei Li; Yueh Hsiung Kuo; Ching Kuo Lee

doi:10.1055/s-0030-1250672

Cytotoxic steroidal saponins from Agave sisalana

Pi Yu Chen, Chin Hui Chen, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo, Ching Kuo Lee

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC₅₀ values of 1.2, 3.8, and 1.5 μM, respectively.

Original language	English
Pages (from-to)	929-933
Number of pages	5
Journal	Planta Medica
Volume	77
Issue number	9
DOIs	https://doi.org/10.1055/s-0030-1250672
Publication status	Published - 2011

Keywords

Agavaceae
Agave sisalana
MCF-7 cells
NCI-H460 cells
SF-268 cells
steroidal saponin

ASJC Scopus subject areas

Drug Discovery
Analytical Chemistry
Molecular Medicine
Complementary and alternative medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1055/s-0030-1250672

Cite this

@article{a2714e92cb4e448c90107e328acc1171,

title = "Cytotoxic steroidal saponins from Agave sisalana",

abstract = "Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC50 values of 1.2, 3.8, and 1.5 μM, respectively.",

keywords = "Agavaceae, Agave sisalana, MCF-7 cells, NCI-H460 cells, SF-268 cells, steroidal saponin",

author = "Chen, {Pi Yu} and Chen, {Chin Hui} and Kuo, {Ching Chuan} and Zong-Huei Li and Kuo, {Yueh Hsiung} and Lee, {Ching Kuo}",

year = "2011",

doi = "10.1055/s-0030-1250672",

language = "English",

volume = "77",

pages = "929--933",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "9",

}

TY - JOUR

T1 - Cytotoxic steroidal saponins from Agave sisalana

AU - Chen, Pi Yu

AU - Chen, Chin Hui

AU - Kuo, Ching Chuan

AU - Li, Zong-Huei

AU - Kuo, Yueh Hsiung

AU - Lee, Ching Kuo

PY - 2011

Y1 - 2011

N2 - Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC50 values of 1.2, 3.8, and 1.5 μM, respectively.

AB - Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC50 values of 1.2, 3.8, and 1.5 μM, respectively.

KW - Agavaceae

KW - Agave sisalana

KW - MCF-7 cells

KW - NCI-H460 cells

KW - SF-268 cells

KW - steroidal saponin

UR - http://www.scopus.com/inward/record.url?scp=79958807490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958807490&partnerID=8YFLogxK

U2 - 10.1055/s-0030-1250672

DO - 10.1055/s-0030-1250672

M3 - Article

C2 - 21243587

AN - SCOPUS:79958807490

SN - 0032-0943

VL - 77

SP - 929

EP - 933

JO - Planta Medica

JF - Planta Medica

IS - 9

ER -

Cytotoxic steroidal saponins from Agave sisalana

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this