Abstract
(Figure presented) A novel C35-terpene, designated as cryptotrione (1), with an unprecedented skeleton possessing an abietane diterpene with a unique bicyclic sesquiterpene, is identified from the bark of Cryptomeria japonica. The carbon skeleton of 1 represents a new structural entity, and this is an intriguing addition to the structurally diverse diterpene-sesquiterpene class. A unique biosynthetic pathway is proposed to support the production of this phytocompound. Notably, 1 exhibits anticancer activity with an IC50 value of 6.44 ± 2.23 μM.
Original language | English |
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Pages (from-to) | 2786-2789 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 12 |
Issue number | 12 |
DOIs | |
Publication status | Published - Jun 2010 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry