Cytotoxic constituents from Podocarpus fasciculus

Yu Jen Kuo; Shy Yuan Hwang; Ming Der Wu; Chia Ching Liao; Yu Han Liang; Yao Haur Kuo; Hsiu O. Ho

doi:10.1248/cpb.56.585

Cytotoxic constituents from Podocarpus fasciculus

Yu Jen Kuo, Shy Yuan Hwang, Ming Der Wu, Chia Ching Liao, Yu Han Liang, Yao Haur Kuo, Hsiu O. Ho

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

A new diterpene, 16-hydroxy communic acid (1), along with thirty one known compounds including five norditerpenes (2-6), twenty two flavonoids containing four biflavonoids (7-10), nine monoflavonoids (11-19) and nine flavanoid glycosides (20-28), as well as four phenolic constituents (29-32) were isolated from the 95% ethanolic extract of Podocarpus fasciculus. The structure of 1 was elucidated using spectral methods. Of these isolates, nagilactone C (2) showed the most significant inhibitory effects against DLD cells (human colon carcinoma) (ED₅₀=2.57 μg/ml) and compounds 7, 8, 10, 11, and 12 had moderate cytotoxic activity against human KB (human oral epithelium carcinoma), Hela (human cervical carcinoma), Hepa (human hepatoma), DLD (colon carcinoma), and A-549 (human lung carcinoma) tumor cell lines. Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed.

Original language	English
Pages (from-to)	585-588
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	56
Issue number	4
DOIs	https://doi.org/10.1248/cpb.56.585
Publication status	Published - Apr 2008

Keywords

16-hydroxy communic acid
Cytotoxic activity
Podocarpaceae
Podocarpus fasciculus

ASJC Scopus subject areas

General Chemistry
Drug Discovery

Access to Document

10.1248/cpb.56.585

Cite this

@article{7ea16829962846a29746615f8d07cf89,

title = "Cytotoxic constituents from Podocarpus fasciculus",

abstract = "A new diterpene, 16-hydroxy communic acid (1), along with thirty one known compounds including five norditerpenes (2-6), twenty two flavonoids containing four biflavonoids (7-10), nine monoflavonoids (11-19) and nine flavanoid glycosides (20-28), as well as four phenolic constituents (29-32) were isolated from the 95% ethanolic extract of Podocarpus fasciculus. The structure of 1 was elucidated using spectral methods. Of these isolates, nagilactone C (2) showed the most significant inhibitory effects against DLD cells (human colon carcinoma) (ED50=2.57 μg/ml) and compounds 7, 8, 10, 11, and 12 had moderate cytotoxic activity against human KB (human oral epithelium carcinoma), Hela (human cervical carcinoma), Hepa (human hepatoma), DLD (colon carcinoma), and A-549 (human lung carcinoma) tumor cell lines. Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed.",

keywords = "16-hydroxy communic acid, Cytotoxic activity, Podocarpaceae, Podocarpus fasciculus",

author = "Kuo, {Yu Jen} and Hwang, {Shy Yuan} and Wu, {Ming Der} and Liao, {Chia Ching} and Liang, {Yu Han} and Kuo, {Yao Haur} and Ho, {Hsiu O.}",

year = "2008",

month = apr,

doi = "10.1248/cpb.56.585",

language = "English",

volume = "56",

pages = "585--588",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "4",

}

TY - JOUR

T1 - Cytotoxic constituents from Podocarpus fasciculus

AU - Kuo, Yu Jen

AU - Hwang, Shy Yuan

AU - Wu, Ming Der

AU - Liao, Chia Ching

AU - Liang, Yu Han

AU - Kuo, Yao Haur

AU - Ho, Hsiu O.

PY - 2008/4

Y1 - 2008/4

N2 - A new diterpene, 16-hydroxy communic acid (1), along with thirty one known compounds including five norditerpenes (2-6), twenty two flavonoids containing four biflavonoids (7-10), nine monoflavonoids (11-19) and nine flavanoid glycosides (20-28), as well as four phenolic constituents (29-32) were isolated from the 95% ethanolic extract of Podocarpus fasciculus. The structure of 1 was elucidated using spectral methods. Of these isolates, nagilactone C (2) showed the most significant inhibitory effects against DLD cells (human colon carcinoma) (ED50=2.57 μg/ml) and compounds 7, 8, 10, 11, and 12 had moderate cytotoxic activity against human KB (human oral epithelium carcinoma), Hela (human cervical carcinoma), Hepa (human hepatoma), DLD (colon carcinoma), and A-549 (human lung carcinoma) tumor cell lines. Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed.

AB - A new diterpene, 16-hydroxy communic acid (1), along with thirty one known compounds including five norditerpenes (2-6), twenty two flavonoids containing four biflavonoids (7-10), nine monoflavonoids (11-19) and nine flavanoid glycosides (20-28), as well as four phenolic constituents (29-32) were isolated from the 95% ethanolic extract of Podocarpus fasciculus. The structure of 1 was elucidated using spectral methods. Of these isolates, nagilactone C (2) showed the most significant inhibitory effects against DLD cells (human colon carcinoma) (ED50=2.57 μg/ml) and compounds 7, 8, 10, 11, and 12 had moderate cytotoxic activity against human KB (human oral epithelium carcinoma), Hela (human cervical carcinoma), Hepa (human hepatoma), DLD (colon carcinoma), and A-549 (human lung carcinoma) tumor cell lines. Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed.

KW - 16-hydroxy communic acid

KW - Cytotoxic activity

KW - Podocarpaceae

KW - Podocarpus fasciculus

UR - http://www.scopus.com/inward/record.url?scp=42049087833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42049087833&partnerID=8YFLogxK

U2 - 10.1248/cpb.56.585

DO - 10.1248/cpb.56.585

M3 - Article

C2 - 18379113

AN - SCOPUS:42049087833

SN - 0009-2363

VL - 56

SP - 585

EP - 588

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 4

ER -

Cytotoxic constituents from Podocarpus fasciculus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this