Cytotoxic apigenin derivatives from Chrysopogon aciculatis

Chien Chang Shen; Jing Jy Cheng; Horng Liang Lay; Szu Yuan Wu; Ching Li Ni; Che Ming Teng; Chien Chih Chen

doi:10.1021/np2007796

Cytotoxic apigenin derivatives from Chrysopogon aciculatis

Chien Chang Shen, Jing Jy Cheng, Horng Liang Lay, Szu Yuan Wu, Ching Li Ni, Che Ming Teng, Chien Chih Chen

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Four new apigenin derivatives, 7-de-O-methylaciculatin (1), 8-C-β-d-boivinopyranosylapigenin (2), aciculatinone (3), and 4′-O-glucosylaciculatin (4), along with eight known compounds, apigenin-8-carbaldehyde (5), kaempferol, tricin, taxifolin, 6,7,4′- trihydroxyflavone, trans-oxyresveratrol, aciculatin, and luteolin-7-sulfate, were isolated from an ethanolic extract of Chrysopogon aciculatis. Their chemical structures were elucidated by spectroscopic methods. Among the known compounds, the natural occurrence of apigenin-8-carbaldehyde and luteolin-7-sulfate is demonstrated for the first time. Some of the isolates were evaluated for cytotoxic activity against human cancer cell lines including MCF-7, H460, HT-29, and CEM.

Original language	English
Pages (from-to)	198-201
Number of pages	4
Journal	Journal of Natural Products
Volume	75
Issue number	2
DOIs	https://doi.org/10.1021/np2007796
Publication status	Published - Feb 24 2012
Externally published	Yes

ASJC Scopus subject areas

Drug Discovery
Analytical Chemistry
Molecular Medicine
Complementary and alternative medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/np2007796

Cite this

@article{876dfe40426f47a2816bcfeba89d4d14,

title = "Cytotoxic apigenin derivatives from Chrysopogon aciculatis",

abstract = "Four new apigenin derivatives, 7-de-O-methylaciculatin (1), 8-C-β-d-boivinopyranosylapigenin (2), aciculatinone (3), and 4′-O-glucosylaciculatin (4), along with eight known compounds, apigenin-8-carbaldehyde (5), kaempferol, tricin, taxifolin, 6,7,4′- trihydroxyflavone, trans-oxyresveratrol, aciculatin, and luteolin-7-sulfate, were isolated from an ethanolic extract of Chrysopogon aciculatis. Their chemical structures were elucidated by spectroscopic methods. Among the known compounds, the natural occurrence of apigenin-8-carbaldehyde and luteolin-7-sulfate is demonstrated for the first time. Some of the isolates were evaluated for cytotoxic activity against human cancer cell lines including MCF-7, H460, HT-29, and CEM.",

author = "Shen, {Chien Chang} and Cheng, {Jing Jy} and Lay, {Horng Liang} and Wu, {Szu Yuan} and Ni, {Ching Li} and Teng, {Che Ming} and Chen, {Chien Chih}",

year = "2012",

month = feb,

day = "24",

doi = "10.1021/np2007796",

language = "English",

volume = "75",

pages = "198--201",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Cytotoxic apigenin derivatives from Chrysopogon aciculatis

AU - Shen, Chien Chang

AU - Cheng, Jing Jy

AU - Lay, Horng Liang

AU - Wu, Szu Yuan

AU - Ni, Ching Li

AU - Teng, Che Ming

AU - Chen, Chien Chih

PY - 2012/2/24

Y1 - 2012/2/24

N2 - Four new apigenin derivatives, 7-de-O-methylaciculatin (1), 8-C-β-d-boivinopyranosylapigenin (2), aciculatinone (3), and 4′-O-glucosylaciculatin (4), along with eight known compounds, apigenin-8-carbaldehyde (5), kaempferol, tricin, taxifolin, 6,7,4′- trihydroxyflavone, trans-oxyresveratrol, aciculatin, and luteolin-7-sulfate, were isolated from an ethanolic extract of Chrysopogon aciculatis. Their chemical structures were elucidated by spectroscopic methods. Among the known compounds, the natural occurrence of apigenin-8-carbaldehyde and luteolin-7-sulfate is demonstrated for the first time. Some of the isolates were evaluated for cytotoxic activity against human cancer cell lines including MCF-7, H460, HT-29, and CEM.

AB - Four new apigenin derivatives, 7-de-O-methylaciculatin (1), 8-C-β-d-boivinopyranosylapigenin (2), aciculatinone (3), and 4′-O-glucosylaciculatin (4), along with eight known compounds, apigenin-8-carbaldehyde (5), kaempferol, tricin, taxifolin, 6,7,4′- trihydroxyflavone, trans-oxyresveratrol, aciculatin, and luteolin-7-sulfate, were isolated from an ethanolic extract of Chrysopogon aciculatis. Their chemical structures were elucidated by spectroscopic methods. Among the known compounds, the natural occurrence of apigenin-8-carbaldehyde and luteolin-7-sulfate is demonstrated for the first time. Some of the isolates were evaluated for cytotoxic activity against human cancer cell lines including MCF-7, H460, HT-29, and CEM.

UR - http://www.scopus.com/inward/record.url?scp=84863231760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863231760&partnerID=8YFLogxK

U2 - 10.1021/np2007796

DO - 10.1021/np2007796

M3 - Article

C2 - 22272829

AN - SCOPUS:84863231760

SN - 0163-3864

VL - 75

SP - 198

EP - 201

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Cytotoxic apigenin derivatives from Chrysopogon aciculatis

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this