The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.02.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.
|Number of pages||3|
|Publication status||Published - Feb 2007|
- Chamaecyparis obtusa var. formosana
- Dimer of monoterpene and norlignan
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry