Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Shih Chang Chien; Jang Yang Chang; Ching Chuan Kuo; Cheng Chih Hsieh; Ning Sun Yang; Yueh Hsiung Kuo

doi:10.1016/j.tetlet.2007.01.011

Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Shih Chang Chien, Jang Yang Chang, Ching Chuan Kuo, Cheng Chih Hsieh, Ning Sun Yang, Yueh Hsiung Kuo

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.0^2.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC₅₀ values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.

Original language	English
Pages (from-to)	1567-1569
Number of pages	3
Journal	Tetrahedron Letters
Volume	48
Issue number	9
DOIs	https://doi.org/10.1016/j.tetlet.2007.01.011
Publication status	Published - Feb 2007
Externally published	Yes

Keywords

Chamaecyparis obtusa var. formosana
Dimer of monoterpene and norlignan
Norlignan

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2007.01.011

Cite this

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title = "Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana",

abstract = "The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.02.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.",

keywords = "Chamaecyparis obtusa var. formosana, Dimer of monoterpene and norlignan, Norlignan",

author = "Chien, {Shih Chang} and Chang, {Jang Yang} and Kuo, {Ching Chuan} and Hsieh, {Cheng Chih} and Yang, {Ning Sun} and Kuo, {Yueh Hsiung}",

note = "Funding Information: The authors thank the National Science Council of the Republic of China, for financial support. ",

year = "2007",

month = feb,

doi = "10.1016/j.tetlet.2007.01.011",

language = "English",

volume = "48",

pages = "1567--1569",

journal = "Tetrahedron Letters",

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number = "9",

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T1 - Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

AU - Chien, Shih Chang

AU - Chang, Jang Yang

AU - Kuo, Ching Chuan

AU - Hsieh, Cheng Chih

AU - Yang, Ning Sun

AU - Kuo, Yueh Hsiung

N1 - Funding Information: The authors thank the National Science Council of the Republic of China, for financial support.

PY - 2007/2

Y1 - 2007/2

N2 - The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.02.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.

AB - The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.02.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.

KW - Chamaecyparis obtusa var. formosana

KW - Dimer of monoterpene and norlignan

KW - Norlignan

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DO - 10.1016/j.tetlet.2007.01.011

M3 - Article

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SN - 0040-4039

VL - 48

SP - 1567

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JO - Tetrahedron Letters

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ER -

Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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