TY - JOUR
T1 - Cytogenetic studies and clinical implications in patients with Sézary syndrome
AU - Whang‐Peng, J.
AU - Lutzner, M.
AU - Edelson, R.
AU - Knutsen, T.
PY - 1976/1/1
Y1 - 1976/1/1
N2 - Chromosome studies were carried out on 11 National Institutes of Health (N.I.H.) patients who had the diagnosis of Sézary syndrome. Heteroploidy, multiple markers including minute and ring chromosomes, and a lack of modality and clone formation, were the common chromosomal findings in this syndrome. Abundant spontaneous division of heteroploid cells in unstimulated peripheral blood cultures, a high percentage of heteroploid cells in stimulated culture, and finally, clone formation, are signs of a fulminant process and lead to the terminal phase of this disease. Early chemotherapeutic eradication of these heteroploid neoplastic cells would, therefore, be the treatment of choice in this disease.
AB - Chromosome studies were carried out on 11 National Institutes of Health (N.I.H.) patients who had the diagnosis of Sézary syndrome. Heteroploidy, multiple markers including minute and ring chromosomes, and a lack of modality and clone formation, were the common chromosomal findings in this syndrome. Abundant spontaneous division of heteroploid cells in unstimulated peripheral blood cultures, a high percentage of heteroploid cells in stimulated culture, and finally, clone formation, are signs of a fulminant process and lead to the terminal phase of this disease. Early chemotherapeutic eradication of these heteroploid neoplastic cells would, therefore, be the treatment of choice in this disease.
UR - https://www.scopus.com/pages/publications/0017082059
UR - https://www.scopus.com/pages/publications/0017082059#tab=citedBy
U2 - 10.1002/1097-0142(197608)38:2<861::AID-CNCR2820380233>3.0.CO;2-M
DO - 10.1002/1097-0142(197608)38:2<861::AID-CNCR2820380233>3.0.CO;2-M
M3 - Article
C2 - 135639
AN - SCOPUS:0017082059
SN - 0008-543X
VL - 38
SP - 861
EP - 867
JO - Cancer
JF - Cancer
IS - 2
ER -
