TY - JOUR
T1 - Cytogenetic characterization of selected small round cell tumors of childhood
AU - Whang-Peng, J.
AU - Triche, T. J.
AU - Knutsen, T.
AU - Miser, J.
AU - Kao-Shan, S.
AU - Tsai, S.
AU - Israel, M. A.
PY - 1986/4/1
Y1 - 1986/4/1
N2 - Small, round, blue-cell tumors (SRCT), including rhabdomyosarcoma, Ewing's sarcoma of bone and soft tissue, mesenchymal chondrosarcoma, small cell osteosarcoma, hemangiopericytoma, neuroblastoma, peripheral neurectodermal tumor (peripheral neuroepithelioma of bone and soft tissue), and the malignant small cell tumor of the thoracopulmonary region described by Askin (Askin's tumor), are often difficult to distinguish by light microscopy. We have evaluated the cytogenetics of these tumors by studying 24 tumor explants in short-term culture and 22 tumor cell lines. In Ewing's sarcoma (a tumor of unknown histogenesis), and in peripheral neuroepithelioma and Askin's tumor (tumors with evidence of neural origin), we have observed an indistinguishable t(11;22) translocation.
AB - Small, round, blue-cell tumors (SRCT), including rhabdomyosarcoma, Ewing's sarcoma of bone and soft tissue, mesenchymal chondrosarcoma, small cell osteosarcoma, hemangiopericytoma, neuroblastoma, peripheral neurectodermal tumor (peripheral neuroepithelioma of bone and soft tissue), and the malignant small cell tumor of the thoracopulmonary region described by Askin (Askin's tumor), are often difficult to distinguish by light microscopy. We have evaluated the cytogenetics of these tumors by studying 24 tumor explants in short-term culture and 22 tumor cell lines. In Ewing's sarcoma (a tumor of unknown histogenesis), and in peripheral neuroepithelioma and Askin's tumor (tumors with evidence of neural origin), we have observed an indistinguishable t(11;22) translocation.
UR - http://www.scopus.com/inward/record.url?scp=0022623831&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022623831&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(86)90001-4
DO - 10.1016/0165-4608(86)90001-4
M3 - Article
C2 - 3004699
AN - SCOPUS:0022623831
SN - 0165-4608
VL - 21
SP - 185
EP - 208
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 3
ER -