Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis

Jeng Hsien Yen; Wen Chun Tsai; Chung Jen Chen; Chia Hui Lin; Tsan Teng Ou; Chaur Jong Hu; Hong Wen Liu

doi:10.1016/S0165-2478(03)00071-3

Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis

Jeng Hsien Yen, Wen Chun Tsai, Chung Jen Chen, Chia Hui Lin, Tsan Teng Ou, Chaur Jong Hu, Hong Wen Liu

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Objectives: To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. Methods: The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls by polymerase chain reaction (PCR)/restriction fragment length polymorphisms (RFLP) methods. Results: The genotype frequency of CYP1A1 4887C/A was significantly lower in patients with AS than in controls. The phenotype frequency of CYP1A1 4887A also tended to be decreased in patients with AS. There were no significant differences in the genotype, allele, and phenotype frequencies of MnSOD gene polymorphisms between patients with AS and controls. Conclusion: CYP1A1 4887A may be a protective factor for the development of AS in Taiwan. However, MnSOD gene polymorphisms are not associated with the susceptibility to AS.

Original language	English
Pages (from-to)	113-116
Number of pages	4
Journal	Immunology Letters
Volume	88
Issue number	2
DOIs	https://doi.org/10.1016/S0165-2478(03)00071-3
Publication status	Published - Aug 5 2003
Externally published	Yes

Keywords

Ankylosing spondylitis
Cytochrome
Manganese superoxide dismutase

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/S0165-2478(03)00071-3

Cite this

@article{d4fda04bf1434ea1aa8c2ca271778574,

title = "Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis",

abstract = "Objectives: To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. Methods: The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls by polymerase chain reaction (PCR)/restriction fragment length polymorphisms (RFLP) methods. Results: The genotype frequency of CYP1A1 4887C/A was significantly lower in patients with AS than in controls. The phenotype frequency of CYP1A1 4887A also tended to be decreased in patients with AS. There were no significant differences in the genotype, allele, and phenotype frequencies of MnSOD gene polymorphisms between patients with AS and controls. Conclusion: CYP1A1 4887A may be a protective factor for the development of AS in Taiwan. However, MnSOD gene polymorphisms are not associated with the susceptibility to AS.",

keywords = "Ankylosing spondylitis, Cytochrome, Manganese superoxide dismutase",

author = "Yen, {Jeng Hsien} and Tsai, {Wen Chun} and Chen, {Chung Jen} and Lin, {Chia Hui} and Ou, {Tsan Teng} and Hu, {Chaur Jong} and Liu, {Hong Wen}",

note = "Funding Information: The work was supported by a grant from Kaohsiung Municipal United Hospital, Taiwan.",

year = "2003",

month = aug,

day = "5",

doi = "10.1016/S0165-2478(03)00071-3",

language = "English",

volume = "88",

pages = "113--116",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis

AU - Yen, Jeng Hsien

AU - Tsai, Wen Chun

AU - Chen, Chung Jen

AU - Lin, Chia Hui

AU - Ou, Tsan Teng

AU - Hu, Chaur Jong

AU - Liu, Hong Wen

N1 - Funding Information: The work was supported by a grant from Kaohsiung Municipal United Hospital, Taiwan.

PY - 2003/8/5

Y1 - 2003/8/5

N2 - Objectives: To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. Methods: The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls by polymerase chain reaction (PCR)/restriction fragment length polymorphisms (RFLP) methods. Results: The genotype frequency of CYP1A1 4887C/A was significantly lower in patients with AS than in controls. The phenotype frequency of CYP1A1 4887A also tended to be decreased in patients with AS. There were no significant differences in the genotype, allele, and phenotype frequencies of MnSOD gene polymorphisms between patients with AS and controls. Conclusion: CYP1A1 4887A may be a protective factor for the development of AS in Taiwan. However, MnSOD gene polymorphisms are not associated with the susceptibility to AS.

AB - Objectives: To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. Methods: The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls by polymerase chain reaction (PCR)/restriction fragment length polymorphisms (RFLP) methods. Results: The genotype frequency of CYP1A1 4887C/A was significantly lower in patients with AS than in controls. The phenotype frequency of CYP1A1 4887A also tended to be decreased in patients with AS. There were no significant differences in the genotype, allele, and phenotype frequencies of MnSOD gene polymorphisms between patients with AS and controls. Conclusion: CYP1A1 4887A may be a protective factor for the development of AS in Taiwan. However, MnSOD gene polymorphisms are not associated with the susceptibility to AS.

KW - Ankylosing spondylitis

KW - Cytochrome

KW - Manganese superoxide dismutase

UR - http://www.scopus.com/inward/record.url?scp=0038106237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038106237&partnerID=8YFLogxK

U2 - 10.1016/S0165-2478(03)00071-3

DO - 10.1016/S0165-2478(03)00071-3

M3 - Article

C2 - 12880680

AN - SCOPUS:0038106237

SN - 0165-2478

VL - 88

SP - 113

EP - 116

JO - Immunology Letters

JF - Immunology Letters

IS - 2

ER -

Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this