CWR22: Androgen-dependent Xenograft Model Derived from a Primary Human Prostatic Carcinoma

Mark A. Wainstein, Feng He, Robinson D, Hsing-Jien Kung, Stuart Schwartz, Joseph M. Giaconia, Nancy L. Edgehouse, Theresa P. Pretlow, Donald R. Bodner, Elroy D. Kursh, Martin I. Resnick, Allen Seftel, Thomas G. Pretlow

Research output: Contribution to journalArticlepeer-review

210 Citations (Scopus)


The long-term propagation of primary human prostate cancer (PCA) in vivo or in vitro has been rare. Most such PC As are phenotypically different from most PCAs in humans; i.e., they make little prostate specific antigen and respond little, if at all, to androgen deprivation. A serially transplantable, primary human PCA, designated CWR22, exhibits a clonal cytogenetic aberration, causes high elevations of prostate specific antigen in the peripheral blood of nude mice, and is unusually responsive to androgen deprivation as compared with other xenografts. Studies of mRNA from CWR22 have demonstrated the expression of prostate specific antigen and the epidermal growth factor receptor family including erbB1/epidermal growth factor receptor, erbB2/neu, and erbB3, but not erbB4. A ligand for these receptors, the neu differentiation factor, is also expressed.

Original languageEnglish
Pages (from-to)6049-6052
Number of pages4
JournalCancer Research
Issue number23
Publication statusPublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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