TY - JOUR
T1 - CWR22
T2 - Androgen-dependent Xenograft Model Derived from a Primary Human Prostatic Carcinoma
AU - Wainstein, Mark A.
AU - He, Feng
AU - D, Robinson
AU - Kung, Hsing-Jien
AU - Schwartz, Stuart
AU - Giaconia, Joseph M.
AU - Edgehouse, Nancy L.
AU - Pretlow, Theresa P.
AU - Bodner, Donald R.
AU - Kursh, Elroy D.
AU - Resnick, Martin I.
AU - Seftel, Allen
AU - Pretlow, Thomas G.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - The long-term propagation of primary human prostate cancer (PCA) in vivo or in vitro has been rare. Most such PC As are phenotypically different from most PCAs in humans; i.e., they make little prostate specific antigen and respond little, if at all, to androgen deprivation. A serially transplantable, primary human PCA, designated CWR22, exhibits a clonal cytogenetic aberration, causes high elevations of prostate specific antigen in the peripheral blood of nude mice, and is unusually responsive to androgen deprivation as compared with other xenografts. Studies of mRNA from CWR22 have demonstrated the expression of prostate specific antigen and the epidermal growth factor receptor family including erbB1/epidermal growth factor receptor, erbB2/neu, and erbB3, but not erbB4. A ligand for these receptors, the neu differentiation factor, is also expressed.
AB - The long-term propagation of primary human prostate cancer (PCA) in vivo or in vitro has been rare. Most such PC As are phenotypically different from most PCAs in humans; i.e., they make little prostate specific antigen and respond little, if at all, to androgen deprivation. A serially transplantable, primary human PCA, designated CWR22, exhibits a clonal cytogenetic aberration, causes high elevations of prostate specific antigen in the peripheral blood of nude mice, and is unusually responsive to androgen deprivation as compared with other xenografts. Studies of mRNA from CWR22 have demonstrated the expression of prostate specific antigen and the epidermal growth factor receptor family including erbB1/epidermal growth factor receptor, erbB2/neu, and erbB3, but not erbB4. A ligand for these receptors, the neu differentiation factor, is also expressed.
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M3 - Article
C2 - 7525052
AN - SCOPUS:0028053632
SN - 0008-5472
VL - 54
SP - 6049
EP - 6052
JO - Journal of Cancer Research
JF - Journal of Cancer Research
IS - 23
ER -
