TY - JOUR
T1 - Curcumin-laden dual-targeting fucoidan/chitosan nanocarriers for inhibiting brain inflammation via intranasal delivery
AU - Don, Trong Ming
AU - Chang, Wan Ju
AU - Jheng, Pei Ru
AU - Huang, Yi Cheng
AU - Chuang, Er Yuan
N1 - Funding Information:
This research work was financially supported by the Ministry of Science and Technology in Taiwan ( MOST 108-2320-B-038-061-MY3 , 108-2221-E-038-017-MY3 and MOST 107-2314-B-019-001-MY3 ) and by the University System of Taipei Joint Research Program ( USTP-NTOU-TMU-109-02 ).
Publisher Copyright:
© 2021
PY - 2021/6
Y1 - 2021/6
N2 - Curcumin can reduce the production of brain inflammatory mediators and symptoms of brain diseases. However, a large amount of free curcumin needs to be administered to achieve an effective level in the brain because of its poor water-solubility. Fucoidan and chitosan were reported to respectively target P-selectin and acidic microenvironment expressed by pathologically inflammatory cells/tissues. Herein, the self-assembly of chitosan and fucoidan which could encapsulate curcumin was developed to form the multi-stimuli-responsive nanocarriers, and their pathological pH- and P-selectin-responsive aspects were characterized. Through intranasal delivery to the brain, these curcumin-containing chitosan/fucoidan nanocarriers with dual pH-/P-selectin-targeting properties to the brain lesions improved drug delivery, distribution, and accumulation in the inflammatory brain lesions as evidenced by an augmented inhibitory effect against brain inflammation. This promising multifunctional nanocarrier with a novel drug-delivery route should allow potential clinical biomedical uses by neurosurgeon in the future.
AB - Curcumin can reduce the production of brain inflammatory mediators and symptoms of brain diseases. However, a large amount of free curcumin needs to be administered to achieve an effective level in the brain because of its poor water-solubility. Fucoidan and chitosan were reported to respectively target P-selectin and acidic microenvironment expressed by pathologically inflammatory cells/tissues. Herein, the self-assembly of chitosan and fucoidan which could encapsulate curcumin was developed to form the multi-stimuli-responsive nanocarriers, and their pathological pH- and P-selectin-responsive aspects were characterized. Through intranasal delivery to the brain, these curcumin-containing chitosan/fucoidan nanocarriers with dual pH-/P-selectin-targeting properties to the brain lesions improved drug delivery, distribution, and accumulation in the inflammatory brain lesions as evidenced by an augmented inhibitory effect against brain inflammation. This promising multifunctional nanocarrier with a novel drug-delivery route should allow potential clinical biomedical uses by neurosurgeon in the future.
KW - Chitosan
KW - Curcumin
KW - Fucoidan
KW - Intranasal to brain drug delivery
KW - Multi-functional nanocarrier
KW - Suppression of brain inflammatory
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U2 - 10.1016/j.ijbiomac.2021.04.045
DO - 10.1016/j.ijbiomac.2021.04.045
M3 - Article
AN - SCOPUS:85104303946
SN - 0141-8130
VL - 181
SP - 835
EP - 846
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -