Cross-linking of DNA in situ as a probe for chromatin structure

Carl Veith Hanson; Che Kun James Shen; John E. Hearst

doi:10.1126/science.935855

Cross-linking of DNA in situ as a probe for chromatin structure

Carl Veith Hanson, Che Kun James Shen, John E. Hearst

Research output: Contribution to journal › Article › peer-review

139 Citations (Scopus)

Abstract

The photochemical cross-linking of DNA in situ in chromatin is blocked over short intervals. Electron microscopy of DNA cross-linked in chromatin reveals the lengths of protected regions and provides a map of their sites along the DNA. Protected regions occur most frequently in tandem and have a basic length of 160 to 200 base pairs.

Original language	English
Pages (from-to)	62-64
Number of pages	3
Journal	Science
Volume	193
Issue number	4247
DOIs	https://doi.org/10.1126/science.935855
Publication status	Published - 1976
Externally published	Yes

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title = "Cross-linking of DNA in situ as a probe for chromatin structure",

abstract = "The photochemical cross-linking of DNA in situ in chromatin is blocked over short intervals. Electron microscopy of DNA cross-linked in chromatin reveals the lengths of protected regions and provides a map of their sites along the DNA. Protected regions occur most frequently in tandem and have a basic length of 160 to 200 base pairs.",

author = "Hanson, {Carl Veith} and Shen, {Che Kun James} and Hearst, {John E.}",

year = "1976",

doi = "10.1126/science.935855",

language = "English",

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journal = "Science",

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AU - Hanson, Carl Veith

AU - Shen, Che Kun James

AU - Hearst, John E.

PY - 1976

Y1 - 1976

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AB - The photochemical cross-linking of DNA in situ in chromatin is blocked over short intervals. Electron microscopy of DNA cross-linked in chromatin reveals the lengths of protected regions and provides a map of their sites along the DNA. Protected regions occur most frequently in tandem and have a basic length of 160 to 200 base pairs.

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DO - 10.1126/science.935855

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JO - Science

JF - Science

IS - 4247

ER -

Cross-linking of DNA in situ as a probe for chromatin structure

Abstract

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