Cross-linking of DNA in situ as a probe for chromatin structure

Carl Veith Hanson, Che Kun James Shen, John E. Hearst

Research output: Contribution to journalArticlepeer-review

138 Citations (Scopus)


The photochemical cross-linking of DNA in situ in chromatin is blocked over short intervals. Electron microscopy of DNA cross-linked in chromatin reveals the lengths of protected regions and provides a map of their sites along the DNA. Protected regions occur most frequently in tandem and have a basic length of 160 to 200 base pairs.

Original languageEnglish
Pages (from-to)62-64
Number of pages3
Issue number4247
Publication statusPublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • General


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