Cortisol awakening response in patients with bipolar disorder during acute episodes and partial remission: A pilot study

Ming Chyi Huang; Shan Chi Chuang; Mei Chih Meg Tseng; Yi Ling Chien; Shih Cheng Liao; Hsi Chung Chen; Po Hsiu Kuo

doi:10.1016/j.psychres.2017.08.084

Cortisol awakening response in patients with bipolar disorder during acute episodes and partial remission: A pilot study

Ming Chyi Huang
, Shan Chi Chuang
, Mei Chih Meg Tseng
, Yi Ling Chien
, Shih Cheng Liao
, Hsi Chung Chen
, Po Hsiu Kuo

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

This exploratory study examined the cortisol awakening response (CAR) in patients with bipolar disorder (BPD) at acute phases and partial remission of manic or depressive episodes. Saliva samples of twenty-seven BPD inpatients and 25 healthy controls were collected to determine the CAR patterns, and 12 patients were sampled again at partial remission. BPD patients exhibited a non-enhanced CAR pattern. Lower cortisol expression and a blunted CAR distinguished bipolar-depressive patients from the controls. The intra-individual follow-up for both patient groups revealed a non-significant improvement in CAR patterns, indicating a trend of a normalized CAR after partial remission for BPD patients.

Original language	English
Pages (from-to)	594-597
Number of pages	4
Journal	Psychiatry Research
Volume	258
DOIs	https://doi.org/10.1016/j.psychres.2017.08.084
Publication status	Published - Dec 2017

Keywords

Bipolar disorder
Cortisol awakening response
Hypothalamic–pituitary–adrenal axis

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2017.08.084

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@article{890540121ab24637a43d1ff179fb8158,

title = "Cortisol awakening response in patients with bipolar disorder during acute episodes and partial remission: A pilot study",

abstract = "This exploratory study examined the cortisol awakening response (CAR) in patients with bipolar disorder (BPD) at acute phases and partial remission of manic or depressive episodes. Saliva samples of twenty-seven BPD inpatients and 25 healthy controls were collected to determine the CAR patterns, and 12 patients were sampled again at partial remission. BPD patients exhibited a non-enhanced CAR pattern. Lower cortisol expression and a blunted CAR distinguished bipolar-depressive patients from the controls. The intra-individual follow-up for both patient groups revealed a non-significant improvement in CAR patterns, indicating a trend of a normalized CAR after partial remission for BPD patients.",

keywords = "Bipolar disorder, Cortisol awakening response, Hypothalamic–pituitary–adrenal axis",

author = "Huang, \{Ming Chyi\} and Chuang, \{Shan Chi\} and Tseng, \{Mei Chih Meg\} and Chien, \{Yi Ling\} and Liao, \{Shih Cheng\} and Chen, \{Hsi Chung\} and Kuo, \{Po Hsiu\}",

note = "Funding Information: This research was supported by grants from the Ministry of Science and Technology (NSC 101-2314-B-532-002-MY2 and MOST 103-2628-B-532-001-MY3 ), and Taipei City Hospital ( 10501-62-040, and 10601-62-018 ), Taipei, Taiwan. Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = dec,

doi = "10.1016/j.psychres.2017.08.084",

language = "English",

volume = "258",

pages = "594--597",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Cortisol awakening response in patients with bipolar disorder during acute episodes and partial remission

T2 - A pilot study

AU - Huang, Ming Chyi

AU - Chuang, Shan Chi

AU - Tseng, Mei Chih Meg

AU - Chien, Yi Ling

AU - Liao, Shih Cheng

AU - Chen, Hsi Chung

AU - Kuo, Po Hsiu

N1 - Funding Information: This research was supported by grants from the Ministry of Science and Technology (NSC 101-2314-B-532-002-MY2 and MOST 103-2628-B-532-001-MY3 ), and Taipei City Hospital ( 10501-62-040, and 10601-62-018 ), Taipei, Taiwan. Publisher Copyright: © 2017 Elsevier B.V.

PY - 2017/12

Y1 - 2017/12

N2 - This exploratory study examined the cortisol awakening response (CAR) in patients with bipolar disorder (BPD) at acute phases and partial remission of manic or depressive episodes. Saliva samples of twenty-seven BPD inpatients and 25 healthy controls were collected to determine the CAR patterns, and 12 patients were sampled again at partial remission. BPD patients exhibited a non-enhanced CAR pattern. Lower cortisol expression and a blunted CAR distinguished bipolar-depressive patients from the controls. The intra-individual follow-up for both patient groups revealed a non-significant improvement in CAR patterns, indicating a trend of a normalized CAR after partial remission for BPD patients.

AB - This exploratory study examined the cortisol awakening response (CAR) in patients with bipolar disorder (BPD) at acute phases and partial remission of manic or depressive episodes. Saliva samples of twenty-seven BPD inpatients and 25 healthy controls were collected to determine the CAR patterns, and 12 patients were sampled again at partial remission. BPD patients exhibited a non-enhanced CAR pattern. Lower cortisol expression and a blunted CAR distinguished bipolar-depressive patients from the controls. The intra-individual follow-up for both patient groups revealed a non-significant improvement in CAR patterns, indicating a trend of a normalized CAR after partial remission for BPD patients.

KW - Bipolar disorder

KW - Cortisol awakening response

KW - Hypothalamic–pituitary–adrenal axis

UR - https://www.scopus.com/pages/publications/85028974383

UR - https://www.scopus.com/pages/publications/85028974383#tab=citedBy

U2 - 10.1016/j.psychres.2017.08.084

DO - 10.1016/j.psychres.2017.08.084

M3 - Article

C2 - 28911851

AN - SCOPUS:85028974383

SN - 0165-1781

VL - 258

SP - 594

EP - 597

JO - Psychiatry Research

JF - Psychiatry Research

ER -

Cortisol awakening response in patients with bipolar disorder during acute episodes and partial remission: A pilot study

Abstract

Keywords

ASJC Scopus subject areas

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