TY - JOUR
T1 - Corrigendum to ‟On-tissue polysulfide visualization by surface-enhanced Raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity” [Redox Biol. 41 (2021) 101926] (Redox Biology (2021) 41, (S2213231721000744), (10.1016/j.redox.2021.101926))
AU - Honda, Kazufumi
AU - Hishiki, Takako
AU - Yamamoto, Sohei
AU - Yamamoto, Takehiro
AU - Miura, Nami
AU - Kubo, Akiko
AU - Itoh, Mai
AU - Chen, Wei Yu
AU - Takano, Masashi
AU - Yoshikawa, Tomoyuki
AU - Kasamatsu, Takahiro
AU - Sonoda, Shinichiro
AU - Yoshizawa, Hirotoshi
AU - Nakamura, Seigo
AU - Itai, Yuichiro
AU - Shiota, Megumi
AU - Koike, Daisuke
AU - Naya, Masayuki
AU - Hayakawa, Noriyo
AU - Naito, Yoshiko
AU - Matsuura, Tomomi
AU - Iwaisako, Keiko
AU - Masui, Toshihiko
AU - Uemoto, Shinji
AU - Nagashima, Kengo
AU - Hashimoto, Yoshinori
AU - Sakuma, Tomohiro
AU - Matsubara, Osamu
AU - Huang, Wilber
AU - Ida, Tomoaki
AU - Akaike, Takaaki
AU - Masugi, Yohei
AU - Sakamoto, Michiie
AU - Kato, Tomoyasu
AU - Ino, Yoshinori
AU - Yoshida, Hiroshi
AU - Tsuda, Hitoshi
AU - Hiraoka, Nobuyoshi
AU - Kabe, Yasuaki
AU - Suematsu, Makoto
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/8
Y1 - 2021/8
N2 - The authors regret that there are 3 grammatical typos in the abstract published. Below please find the corrected abstract: Chemosensitivity to cisplatin derivatives varies among individual patients with intractable malignancies including ovarian cancer, while how to unlock the resistance remain unknown. Ovarian cancer tissues were collected after the debulking surgery in discovery- (n = 135) and validation- (n = 47) cohorts, to be analyzed with high-throughput automated immunohistochemistry which identified cystathionine γ-lyase (CSE) as an independent marker distinguishing non-responders from responders to post-operative platinum-based chemotherapy. We aimed to identify CSE-derived metabolites responsible for chemoresistant mechanisms: gold-nanoparticle (AuN)-based surface-enhanced Raman spectroscopy (SERS) was used to enhance electromagnetic fields which enabled to visualize multiple sulfur-containing metabolites through detecting scattering light from Au–S vibration two-dimensionally. Clear cell carcinoma (CCC) which turned out less sensitive to cisplatin than serous adenocarcinoma was classified into two groups by the intensities of SERS intensities at 480 cm-1; patients with greater intensities displayed the shorter overall survival after the debulking surgery. The SERS signals were eliminated by topically applied monobromobimane that breaks sulfane-sulfur bonds of polysulfides to result in formation of sulfide dibimane which was detected at 580 cm-1, manifesting the presence of polysulfides in cancer tissues. CCC-derived cancer cell lines in culture were resistant against cisplatin, but treatment with ambroxol, an expectorant degrading polysulfides, renders the cells CDDP-susceptible. Co-administration of ambroxol with cisplatin significantly suppressed growth of cancer xenografts in nude mice. Furthermore, polysulfides, but neither glutathione nor hypotaurine, attenuated cisplatin-induced disturbance of DNA supercoiling. Polysulfide detection by on-tissue SERS thus enables to predict prognosis of cisplatin-based chemotherapy. The current findings suggest polysulfide degradation as a stratagem unlocking cisplatin chemoresistance. The authors would like to apologise for any inconvenience caused.
AB - The authors regret that there are 3 grammatical typos in the abstract published. Below please find the corrected abstract: Chemosensitivity to cisplatin derivatives varies among individual patients with intractable malignancies including ovarian cancer, while how to unlock the resistance remain unknown. Ovarian cancer tissues were collected after the debulking surgery in discovery- (n = 135) and validation- (n = 47) cohorts, to be analyzed with high-throughput automated immunohistochemistry which identified cystathionine γ-lyase (CSE) as an independent marker distinguishing non-responders from responders to post-operative platinum-based chemotherapy. We aimed to identify CSE-derived metabolites responsible for chemoresistant mechanisms: gold-nanoparticle (AuN)-based surface-enhanced Raman spectroscopy (SERS) was used to enhance electromagnetic fields which enabled to visualize multiple sulfur-containing metabolites through detecting scattering light from Au–S vibration two-dimensionally. Clear cell carcinoma (CCC) which turned out less sensitive to cisplatin than serous adenocarcinoma was classified into two groups by the intensities of SERS intensities at 480 cm-1; patients with greater intensities displayed the shorter overall survival after the debulking surgery. The SERS signals were eliminated by topically applied monobromobimane that breaks sulfane-sulfur bonds of polysulfides to result in formation of sulfide dibimane which was detected at 580 cm-1, manifesting the presence of polysulfides in cancer tissues. CCC-derived cancer cell lines in culture were resistant against cisplatin, but treatment with ambroxol, an expectorant degrading polysulfides, renders the cells CDDP-susceptible. Co-administration of ambroxol with cisplatin significantly suppressed growth of cancer xenografts in nude mice. Furthermore, polysulfides, but neither glutathione nor hypotaurine, attenuated cisplatin-induced disturbance of DNA supercoiling. Polysulfide detection by on-tissue SERS thus enables to predict prognosis of cisplatin-based chemotherapy. The current findings suggest polysulfide degradation as a stratagem unlocking cisplatin chemoresistance. The authors would like to apologise for any inconvenience caused.
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UR - http://www.scopus.com/inward/citedby.url?scp=85108303569&partnerID=8YFLogxK
U2 - 10.1016/j.redox.2021.102028
DO - 10.1016/j.redox.2021.102028
M3 - Comment/debate
C2 - 34087755
AN - SCOPUS:85108303569
SN - 2213-2317
VL - 44
JO - Redox Biology
JF - Redox Biology
M1 - 102028
ER -
