Correlations of serum lipids, uric acid, and albumin among mothers, offspring, and siblings in Taipei, Taiwan

The purpose of this study was to investigate the correlations of serum lipids, uric acid, and albumin, among mothers (n = 111), offspring (n = 208), and siblings (n = 57) in Taipei, Taiwan. Analytical items included serum triglyceride, serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, uric acid, and albumin. Statistical analysis was performed according to the SAS UNIVARIATE procedure; while regression coefficient, parent-offspring regressions, paired-comparison and heritability were estimated. These results show higher heritabilities of four types of serum lipids, uric acid and albumin between mothers and testers (b(YX)) or siblings (b(ZX)) by parent-offspring regression analysis. Regression coefficients (b(YX)) of six characters were significantly different (p < 0.05 - 0.01). Regression coefficients (b(ZX)) for total cholesterol, low-density lipoprotein cholesterol, uric acid, and albumin were significantly different (p < 0.05 - 0.01), showing the result of genetic control, because their heritabilities were very high at 0.75 ~ 1.0, 0.77 ~ 1.0, 0.96 ~ 1.0, and 0.48 ~ 0.82, respectively. This study disclosed that the serum lipids of children in Taipei, Taiwan were significantly correlated with that of parents, which may be attributed to the result of genetic control.